Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM13552
Substrate
BDBM13574
Meas. Tech.
Serine Protease Inhibition Assay
Ki
40±n/a nM
Citation
 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett 15:817-22 (2005) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM13552
Synonyms:
(2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido]-2-phenylacetic acid | phenylglycine amide compound 9 | phenylglycine deriv. 1
Type:
Small organic molecule
Emp. Form.:
C31H30N4O5
Mol. Mass.:
538.5937
SMILES:
COc1cc(ccc1OCc1ccccc1)[C@@H](Nc1ccc(cc1)C(N)=N)C(=O)N[C@H](C(O)=O)c1ccccc1 |r|
Structure:
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Substrate
Name:
BDBM13574
Synonyms:
(2S)-6-amino-2-[(2S)-2-[(2R)-2-amino-3-methylbutanamido]-4-methylpentanamido]-N-(4-nitrophenyl)hexanamide dihydrochloride | Chromogenic Substrate S-2251 | H-D-Valyl-L-leucyl-L-lysine-p-Nitroaniline dihydrochloride
Type:
Small organic molecule
Emp. Form.:
C23H38N6O5
Mol. Mass.:
478.585
SMILES:
CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
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