Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50007566
Substrate
n/a
Meas. Tech.
ChEMBL_58695 (CHEMBL672661)
IC50
108±n/a nM
Citation
 Lowe, JA; Seeger, TF; Nagel, AA; Howard, HR; Seymour, PA; Heym, JH; Ewing, FE; Newman, ME; Schmidt, AW; Furman, JS 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem 34:1860-6 (1991) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50007566
Synonyms:
1-{2-[4-(2-Methyl-thiazol-4-yl)-phenyl]-ethyl}-4-naphthalen-1-yl-piperazine | CHEMBL54910
Type:
Small organic molecule
Emp. Form.:
C26H27N3S
Mol. Mass.:
413.578
SMILES:
Cc1nc(cs1)-c1ccc(CCN2CCN(CC2)c2cccc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: