Reaction Details Report a problem with these data
Target
Vesicular acetylcholine transporter
Ligand
BDBM50009596
Substrate
n/a
Meas. Tech.
ChEBML_213552
IC50
1400±n/a nM
Citation
 Efange, SM; Michelson, RH; Dutta, AK; Parsons, SM Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport. J Med Chem 34:2638-43 (1991) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
TorVAChT | VACHT_TETCF | VAChT
Type:
PROTEIN
Mol. Mass.:
56111.93
Organism:
Torpedo californica
Description:
ChEMBL_1503355
Residue:
515
Sequence:
MGVTMAVGLAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVIVPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAILQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAVLFAARSLQGLGSAFADTSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCLLDGILLLMVVTPFASRTRENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNWMKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIPACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALGPIMAGQIVHDLGFVQLNLGMGLVNILYAPALLFLRNVCQMKPSLSERNILLEEGPKGLYDTIIMEERKAAKEPHGSSSGNHSVHAVLSDQEGYSE
  
Inhibitor
Name:
BDBM50009596
Synonyms:
1-Naphthalen-1-yl-3-(4-phenyl-piperidin-1-yl)-propan-2-ol | CHEMBL314881
Type:
Small organic molecule
Emp. Form.:
C24H27NO
Mol. Mass.:
345.4773
SMILES:
OC(CN1CCC(CC1)c1ccccc1)Cc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: