Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50012244
Substrate
n/a
Meas. Tech.
ChEBML_54898
IC50
35000±n/a nM
Citation
Patil, SD; Jones, C; Nair, MG; Galivan, J; Maley, F; Kisliuk, RL; Gaumont, Y; Duch, D; Ferone, R Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. J Med Chem 32:1284-9 (1989) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
Inhibitor
Name:
BDBM50012244
Synonyms:
2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid | 2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid(DMPDDF) | CHEMBL25889
Type:
Small organic molecule
Emp. Form.:
C25H24N4O6
Mol. Mass.:
476.4813
SMILES:
Cc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1