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Target
Integrase
Ligand
BDBM50237605
Substrate
n/a
Meas. Tech.
ChEMBL_455147 (CHEMBL887177)
IC50
204000±n/a nM
Citation
 Sriram, D; Yogeeswari, P; Senchani, G; Banerjee, D Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase. Bioorg Med Chem Lett 17:2372-5 (2007) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50237605
Synonyms:
Achromycin | Achromycin V | CHEBI:27902 | Cyclopar | E701 | Economycin | Liquamycin | Panmycin | Supramycin | Sustamycin | Tetrabid Organon | Tetracycline | Tetracyn | Vetquamycin
Type:
Small organic molecule
Emp. Form.:
C22H24N2O8
Mol. Mass.:
444.4346
SMILES:
[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)c1c(O)cccc1[C@@]3(C)O |r,t:5,16|
Structure:
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