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TargetThymidylate synthase/GAR transformylase/AICAR transformylase
LigandBDBM50231342
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209653
Ki 0.100000±n/a nM
Citation Pendergast, WDickerson, SHJohnson, JVDev, IKFerone, RDuch, DSSmith, GK Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives. J Med Chem36:3464-71 (1993) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase/GAR transformylase/AICAR transformylase
Name:Thymidylate synthase/GAR transformylase/AICAR transformylase
Synonyms:TS | TSase | Thymidylate synthase (TS)
Type:Enzyme
Mol. Mass.:35718.07
Organism:Homo sapiens (Human)
Description:n/a
Residue:313
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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  Blast E-value cutoff:
BDBM50231342
NameBDBM50231342
Synonyms:CHEMBL118750
TypeSmall organic molecule
Emp. Form.C24H21N5O8S
Mol. Mass.539.517
SMILES[H][C@@](CCC(O)=O)(NC(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc2ccc3nc(N)nc(O)c3c2c1)C(O)=O
Structure
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n/a