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Found 248 with Last Name = 'smith' and Initial = 'gk'
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040857((S)-2-{2-Fluoro-4-[(3-methyl-1-oxo-1,2-dihydro-ben...)
Affinity DataKi:  0.0900nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040861((S)-2-(5-(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUIN...)
Affinity DataKi:  0.0900nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040865((S)-2-{4-[(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quin...)
Affinity DataKi:  0.440nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coli.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of AURAMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040860((S)-2-({5-[(3-Methyl-1-oxo-1,2-dihydro-benzo[f]qui...)
Affinity DataKi:  1.10nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040863((S)-2-{4-[(3-Amino-1-oxo-1,2-dihydro-benzo[f]quina...)
Affinity DataKi:  1.20nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coli.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040859((S)-2-{5-[Methyl-(3-methyl-1-oxo-1,2-dihydro-benzo...)
Affinity DataKi:  2.5nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042378(2-[4-(3-Amino-1-oxo-1,2,5,6-tetrahydro-benzo[f]qui...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040862((S)-2-{6-[(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quin...)
Affinity DataKi:  4nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of AURCMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKi:  5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040858((S)-2-[4-(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quina...)
Affinity DataKi:  5.5nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040858((S)-2-[4-(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quina...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042375(2-[4-(3-Methyl-1-oxo-1,2,5,6-tetrahydro-benzo[f]qu...)
Affinity DataKi:  18nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  18nMAssay Description:Inhibition of AURBMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50230985(CHEMBL306705)
Affinity DataKi:  20nMAssay Description:Inhibition of purified human thymidylate synthase (TS) isolated from an Escherichia coli harboring a plasmid with thy A gene cloned from SV40 transfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040864((S)-2-{4-[Methyl-(3-methyl-1-oxo-1,2-dihydro-benzo...)
Affinity DataKi:  22nMAssay Description:The compound was tested for inhibitory activity against thymidylate synthase(purified recombinant human gene) from E. coli.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  30nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042382(2-[4-(3-Amino-1-oxo-1,2,5,6-tetrahydro-benzo[f]qui...)
Affinity DataKi:  57nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042380(2-[4-(3-Amino-8-bromo-1-oxo-1,2,5,6-tetrahydro-ben...)
Affinity DataKi:  79nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231342(CHEMBL118750)
Affinity DataKi:  100nMAssay Description:Inhibition of purified human thymidylate synthase (TS) isolated from an Escherichia coli harboring a plasmid with thy A gene cloned from SV40 transfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042376(2-{[4-(3-Amino-1-oxo-1,2,5,6-tetrahydro-benzo[f]qu...)
Affinity DataKi:  660nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042381(3-Methyl-2H-benzo[f]quinazolin-1-one | CHEMBL41889...)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042383(3-Amino-5,6-dihydro-2H-benzo[f]quinazolin-1-one | ...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042373(2-[4-(3-Methyl-1-oxo-1,2-dihydro-benzo[f]quinazoli...)
Affinity DataKi:  7.37E+3nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042377(3-Amino-8-bromo-5,6-dihydro-2H-benzo[f]quinazolin-...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231341(CHEMBL116508)
Affinity DataKi:  1.64E+4nMAssay Description:Inhibition of purified human thymidylate synthase (TS) isolated from an Escherichia coli harboring a plasmid with thy A gene cloned from SV40 transfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042374(2-{Methyl-[4-(3-methyl-1-oxo-1,2,5,6-tetrahydro-be...)
Affinity DataKi:  1.67E+4nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50042379(3-Methyl-5,6-dihydro-2H-benzo[f]quinazolin-1-one |...)
Affinity DataKi:  3.56E+4nMAssay Description:Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14046(Aminofurazanyl-azabenzimidazole 6m | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14045(Aminofurazanyl-azabenzimidazole 6l | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14044(Aminofurazanyl-azabenzimidazole 6k | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14043(Aminofurazanyl-azabenzimidazole 6j | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14042(Aminofurazanyl-azabenzimidazole 6i | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14047(Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14047(Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...)
Affinity DataIC50:  1.80nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14035(Aminofurazanyl-azabenzimidazole 6c | N-(3-{[2-(4-a...)
Affinity DataIC50:  1.80nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14041(Aminofurazanyl-azabenzimidazole 6h | N-(3-{[2-(4-a...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25494(4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25495(4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14047(Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14040(Aminofurazanyl-azabenzimidazole 6g | N-(3-{[2-(4-a...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25493(4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-y...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14033(4-{1-ethyl-6-methoxy-1H-imidazo[4,5-c]pyridin-2-yl...)
Affinity DataIC50:  4.40nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25492(4-(4-chloro-2-fluorophenyl)-N-(1H-indazol-5-yl)-2-...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14050(N-(1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoro...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25498(4-(4-chloro-2-fluorophenyl)-N-(6-fluoro-1H-indazol...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  6nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25496(4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-y...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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