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Target
Serine protease 1
Ligand
BDBM50071571
Substrate
n/a
Meas. Tech.
ChEBML_213071
Ki
0.430000±n/a nM
Citation
 Ogbu, CO; Qabar, MN; Boatman, PD; Urban, J; Meara, JP; Ferguson, MD; Tulinsky, J; Lum, C; Babu, S; Blaskovich, MA; Nakanishi, H; Ruan, F; Cao, B; Minarik, R; Little, T; Nelson, S; Nguyen, M; Gall, A; Kahn, M Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics. Bioorg Med Chem Lett 8:2321-6 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50071571
Synonyms:
8-Isobutyl-2-(3-methyl-butyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxylic acid {5-amino-1-[2-(4-carbamoyl-phenyl)-ethylaminooxalyl]-pentyl}-amide | CHEMBL75269
Type:
Small organic molecule
Emp. Form.:
C32H47N7O6
Mol. Mass.:
625.7589
SMILES:
CC(C)CCn1c(=O)n2C(CC(C)C)C=CC(C(=O)NC(CCCCN)C(=O)C(=O)NCCc3ccc(cc3)C(N)=O)n2c1=O |c:14|
Structure:
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