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Target
Stress-70 protein, mitochondrial
Ligand
BDBM50539121
Substrate
n/a
Meas. Tech.
ChEMBL_1977650 (CHEMBL4610785)
Kd
500±n/a nM
Citation
 Gnanasekaran, KK; Pouland, T; Bunce, RA; Darrell Berlin, K; Abuskhuna, S; Bhandari, D; Mashayekhi, M; Zhou, DH; Benbrook, DM Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Stress-70 protein, mitochondrial
Synonyms:
75 kDa glucose-regulated protein | GRP-75 | GRP75 | GRP75_HUMAN | HSPA9 | HSPA9B | Heat shock 70 kDa protein 9 | MOT | Mortalin | PBP74 | Peptide-binding protein 74 | Stress-70 protein, mitochondrial | mt-HSP70
Type:
PROTEIN
Mol. Mass.:
73676.63
Organism:
Homo sapiens
Description:
ChEMBL_118002
Residue:
679
Sequence:
MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ
  
Inhibitor
Name:
BDBM50539121
Synonyms:
CHEMBL4646130
Type:
Small organic molecule
Emp. Form.:
C21H26N4O2S
Mol. Mass.:
398.522
SMILES:
CN1c2ccc(NC(=S)Nc3ccc(cc3)[N+]([O-])=O)cc2C(C)(C)CC1(C)C
Structure:
Search PDB for entries with ligand similarity: