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Target
B-cell lymphoma 6 protein
Ligand
BDBM50541995
Substrate
n/a
Meas. Tech.
ChEMBL_1985724 (CHEMBL4619130)
IC50
368±n/a nM
Citation
 Teng, M; Ficarro, SB; Yoon, H; Che, J; Zhou, J; Fischer, ES; Marto, JA; Zhang, T; Gray, NS Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett 11:1269-1273 (2020) [PubMed]  Article 
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
  
Inhibitor
Name:
BDBM50541995
Synonyms:
CHEMBL4644523
Type:
Small organic molecule
Emp. Form.:
C26H27ClN6O6S
Mol. Mass.:
587.047
SMILES:
CNC(=O)COc1cc2cc(Nc3nc(NCc4cccc(c4)S(C)(=O)=O)ncc3Cl)cc(OC)c2n(C)c1=O
Structure:
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