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Target
Adenosine kinase
Ligand
BDBM50174595
Substrate
n/a
Meas. Tech.
ChEMBL_321616 (CHEMBL872316)
IC50
600±n/a nM
Citation
 Boyer, SH; Ugarkar, BG; Solbach, J; Kopcho, J; Matelich, MC; Ollis, K; Gomez-Galeno, JE; Mendonca, R; Tsuchiya, M; Nagahisa, A; Nakane, M; Wiesner, JB; Erion, MD Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues. J Med Chem 48:6430-41 (2005) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50174595
Synonyms:
(4R,5R,6S)-5-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-4-oxa-spiro[2.4]heptane-6,7-diol | CHEMBL373104
Type:
Small organic molecule
Emp. Form.:
C12H13IN4O3
Mol. Mass.:
388.1611
SMILES:
Nc1ncnc2n(cc(I)c12)[C@@H]1OC2(CC2)[C@@H](O)[C@H]1O
Structure:
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