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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM50186929
Substrate
n/a
Meas. Tech.
ChEMBL_376410 (CHEMBL866638)
EC50
0.70±n/a nM
Citation
Yan, L; Huo, P; Doherty, G; Toth, L; Hale, JJ; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Quackenbush, E; Wickham, A; Mandala, SM Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes. Bioorg Med Chem Lett 16:3679-83 (2006) [PubMed] Article
More Info.:
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
Inhibitor
Name:
BDBM50186929
Synonyms:
3-(4-(5-(3-cyano-4-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoic acid | CHEMBL210942
Type:
Small organic molecule
Emp. Form.:
C22H15F6N3O4
Mol. Mass.:
499.3626
SMILES:
Cc1cc(CCC(O)=O)ccc1-c1noc(n1)-c1ccc(OC(C(F)(F)F)C(F)(F)F)c(c1)C#N