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Found 670 with Last Name = 'huo' and Initial = 'p'
TargetCocaine esterase(Homo sapiens (Human))
Shanghai University Of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50552232(CHEMBL4776624)
Affinity DataKi:  68nMAssay Description:Mixed inhibition of hCES2A in human liver microsome assessed as reduction in fluorescein diacetate hydrolysis preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Sus scrofa (Pig))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50552240(CHEMBL4780197)
Affinity DataKi:  120nMAssay Description:Mixed type inhibition of porcine pancreatic lipase using 4MUO as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503648(CHEMBL4474444)
Affinity DataKi:  340nMAssay Description:Inhibition of cathepsin B (unknown origin) using Z-Arg-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503648(CHEMBL4474444)
Affinity DataKi:  720nMAssay Description:Inhibition of cathepsin L (unknown origin) using Z-Phe-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503647(CHEMBL327624)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of cathepsin L (unknown origin) using Z-Phe-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Shanghai University Of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50017698(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human CES2A using 4-methylumbelliferone as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317420(1-Dehydro-10-gingerdione | CHEMBL1094100)
Affinity DataKi:  3.59E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataKi:  3.74E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317423((E)-1-(4-Hydroxy-3-methoxy-phenyl)-tetradec-4-en-3...)
Affinity DataKi:  5.84E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317422(1-Dehydro-6-gingerdione | CHEMBL1096043)
Affinity DataKi:  6.53E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317421(1-Dehydro-8-gingerdione | CHEMBL1096044)
Affinity DataKi:  6.54E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317419(6-Dihydroparadol | CHEMBL1094101)
Affinity DataKi:  9.53E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503647(CHEMBL327624)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of cathepsin B (unknown origin) using Z-Arg-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataKi:  1.17E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50482873(CHEBI:70659 | CHEMBL1271362)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of Influenza A virus (A/California/08/2009(H1N1)) neuraminidase expressed in human 293T cells by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317424((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dodec-4-en-3-on...)
Affinity DataKi:  1.31E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataKi:  1.80E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50482872(CHEBI:70655 | CHEMBL1271157)
Affinity DataKi:  2.49E+4nMAssay Description:Inhibition of Influenza A virus (A/California/08/2009(H1N1)) neuraminidase expressed in human 293T cells by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50482871(CHEBI:66265 | CHEMBL509947)
Affinity DataKi:  3.41E+4nMAssay Description:Inhibition of Influenza A virus (A/California/08/2009(H1N1)) neuraminidase expressed in human 293T cells by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50482882(CHEBI:70658 | CHEMBL463095)
Affinity DataKi:  4.14E+4nMAssay Description:Inhibition of Influenza A virus (A/California/08/2009(H1N1)) neuraminidase expressed in human 293T cells by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503646(CHEMBL4564457)
Affinity DataKi:  5.90E+4nMAssay Description:Competitive inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured at 1 min interval for 20 mins followed by every 15 mins for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50275147(6-Gingerol | BDBM50317427 | CHEMBL446043 | Gingero...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503650(CHEMBL4516952)
Affinity DataKi:  1.46E+5nMAssay Description:Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured at 1 min interval for 20 mins followed by every 15 mins for 2 hrs by fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50320187((2R)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3'...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316529(CHEMBL1095151 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316527(CHEMBL1097841 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316524(CHEMBL1095158 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50320184(CHEMBL1086494 | rac-N-(7'-(2-chlorophenyl)-6'-(4-c...)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316528(CHEMBL1095150 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of cannabinoid CB1 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50320186((2S)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3'...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316525(CHEMBL1095476 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM25737(12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin) using NEPC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316531(CHEMBL1095553 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316532(CHEMBL1095554 | N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50186937(1-(4-((5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl)m...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [33P]S1P binding to S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316520(CHEMBL1095159 | N-[6-(4-Chlorophenyl)-7-(2,4-dichl...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM25737(12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of sEH (unknown origin) expressed in baculovirus expression system incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM22209(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316519(CHEMBL1097456 | N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHL...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316518(CHEMBL1097455 | N-[6-(4-Chlorophenyl)-7-(2,4-dichl...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]CP55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50320185(CHEMBL1085566 | N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOR...)
Affinity DataIC50:  0.700nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316513(CHEMBL1096182 | N-((4R)-6-(4-chlorophenyl)-7-(2,4-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of rat cannabinoid CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185143((+/-)-2-(cis-5-(4-(5-(4-cyclohexylphenyl)-1,2,4-ox...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [33P]S1P from S1P1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185145((+/-)-2-(cis-5-(4-(5-(4-((S)-3,3-difluorocyclopent...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [33P]S1P from S1P1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185524(2-(trans-5-(4-(5-(4-((R)-3,3-difluorocyclopentyl)p...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50185524(2-(trans-5-(4-(5-(4-((R)-3,3-difluorocyclopentyl)p...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM22209(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)
Affinity DataIC50:  1nMAssay Description:Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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