Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50203524
Substrate
n/a
Meas. Tech.
ChEMBL_425538 (CHEMBL911375)
IC50
>5000±n/a nM
Citation
Yao, W; Zhuo, J; Burns, DM; Xu, M; Zhang, C; Li, YL; Qian, DQ; He, C; Weng, L; Shi, E; Lin, Q; Agrios, C; Burn, TC; Caulder, E; Covington, MB; Fridman, JS; Friedman, S; Katiyar, K; Hollis, G; Li, Y; Liu, C; Liu, X; Marando, CA; Newton, R; Pan, M; Scherle, P; Taylor, N; Vaddi, K; Wasserman, ZR; Wynn, R; Yeleswaram, S; Jalluri, R; Bower, M; Zhou, BB; Metcalf, B Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer. J Med Chem 50:603-6 (2007) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN