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Found 1835 with Last Name = 'vaddi' and Initial = 'k'
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50227856((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  6nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26567((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)-1-ben...)
Affinity DataKi:  10nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  12nMAssay Description:Binding affinity to MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  18nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  25nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26565((3S,4S)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi:  43nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26564((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi:  53nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  54nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502498(CHEMBL4518534)
Affinity DataKi:  55nMAssay Description:Binding affinity to human recombinant PRMT5/MEP50 expressed in baculovirus infected High-five cells using histone 4 peptide as substrate assessed as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26562((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1H-indol-3-y...)
Affinity DataKi:  65nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26561((3S,4S)-3-N-hydroxy-4-N-{4-[(2-methyl-1H-indol-3-y...)
Affinity DataKi:  70nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  82nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26566((3S,4S)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)-1-ben...)
Affinity DataKi:  85nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  91nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  97nMAssay Description:Binding affinity to ADAMTS5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26563((3R,4R)-4-N-{4-[(2-ethyl-1H-indol-3-yl)methyl]benz...)
Affinity DataKi:  107nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26573((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...)
Affinity DataKi:  119nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26560((3S,4S)-3-N-hydroxy-4-N-{4-[(2-methyl-1H-indol-3-y...)
Affinity DataKi:  160nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136288((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  209nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  217nMAssay Description:Binding affinity to MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  240nMAssay Description:Binding affinity to MMP10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136279((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  252nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136261((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  296nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataKi:  306nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26561((3S,4S)-3-N-hydroxy-4-N-{4-[(2-methyl-1H-indol-3-y...)
Affinity DataKi:  311nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26572((3R,4R)-4-N-[4-({2-ethylpyrazolo[1,5-a]pyridin-3-y...)
Affinity DataKi:  327nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136262((3R,4S)-1-(1-Methyl-1H-imidazole-4-sulfonyl)-piper...)
Affinity DataKi:  366nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152914(1-Ethynyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-ben...)
Affinity DataKi:  377nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136286((3R,4S)-1-(Furan-2-carbonyl)-piperidine-3,4-dicarb...)
Affinity DataKi: >465nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136261((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  476nMAssay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209971(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataKi:  490nMAssay Description:Binding affinity to dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  490nMAssay Description:Binding affinity to MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152909(1-Allyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-benze...)
Affinity DataKi:  503nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26570((3R,4R)-4-N-[4-({2-cyclopropylimidazo[1,2-a]pyridi...)
Affinity DataKi:  540nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26569((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)imidaz...)
Affinity DataKi:  580nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152930(CHEMBL359569 | N-Hydroxy-2-{1-isobutyl-3-[4-(2-met...)
Affinity DataKi:  603nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26565((3S,4S)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi:  627nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136288((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  642nMAssay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152924(CHEMBL184553 | N-Hydroxy-2-{1-isopropyl-3-[4-(2-me...)
Affinity DataKi:  653nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataKi:  656nMAssay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26574((3R,4R)-4-N-[4-({2-tert-butylpyrazolo[1,5-a]pyridi...)
Affinity DataKi:  726nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152915(CHEMBL185321 | N-Hydroxy-2-{2-[4-(2-methyl-quinoli...)
Affinity DataKi:  753nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152933(CHEMBL364875 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataKi:  753nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152907(2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfon...)
Affinity DataKi:  754nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM26567((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)-1-ben...)
Affinity DataKi:  766nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136285((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  767nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136275((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  768nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136279((3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin...)
Affinity DataKi:  771nMAssay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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