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Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50210084
Substrate
n/a
Meas. Tech.
ChEMBL_443938 (CHEMBL893104)
EC50
23±n/a nM
Citation
 Feng, Z; Mohapatra, S; Klimko, PG; Hellberg, MR; May, JA; Kelly, C; Williams, G; McLaughlin, MA; Sharif, NA Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity. Bioorg Med Chem Lett 17:2998-3002 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT2B | 5-hydroxytryptamine receptor 2B | 5HT2B_RAT | Htr2b | Serotonin 2b (5-HT2b) receptor | Serotonin receptor 2a and 2b (5HT2A and 5HT2B) | Srl
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53668.47
Organism:
RAT
Description:
5-HT2B HTR2B RAT::P30994
Residue:
479
Sequence:
MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
  
Inhibitor
Name:
BDBM50210084
Synonyms:
(R)-1-methyl-2-[8-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-benzo[1,2-b;4,5-b']difuran-4-yl]-ethylamine | CHEMBL234682
Type:
Small organic molecule
Emp. Form.:
C17H17N3O3
Mol. Mass.:
311.3352
SMILES:
C[C@@H](N)Cc1c2ccoc2c(Cc2nc(C)no2)c2ccoc12
Structure:
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