Reaction Details
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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM50240959
Substrate
n/a
Meas. Tech.
ChEMBL_560476 (CHEMBL1020496)
IC50
22000±n/a nM
Citation
Kotthaus, J; Schade, D; Muschick, N; Beitz, E; Clement, B Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem 16:10205-9 (2008) [PubMed] Article More Info.:
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH1_RAT | Ddah | Ddah1 | Dimethylarginine dimethylaminohydrolase 1
Type:
PROTEIN
Mol. Mass.:
31423.16
Organism:
Rattus norvegicus
Description:
ChEMBL_560476
Residue:
285
Sequence:
MAGLSHPSVFGRATHAVVRAPPESLCRHALRRSQGEEVDFARAERQHQLYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADSLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDMAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHLLIPVSNSEMEKVDGLLTCCSVFINKKTDS
Inhibitor
Name:
BDBM50240959
Synonyms:
(S)-2-Amino-5-[N'-(2-methoxy-ethyl)-guanidino]-pentanoic acid | CHEMBL366222 | N-omega-(2-methoxyethyl)-L-arginine | N~5~-{IMINO[(2-METHOXYETHYL)AMINO]METHYL}-L-ORNITHINE
Type:
Small organic molecule
Emp. Form.:
C9H20N4O3
Mol. Mass.:
232.2801
SMILES:
COCCNC(N)=NCCC[C@H](N)C(O)=O |r,w:7.7|
Structure:
