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Target
Glycogen phosphorylase, liver form
Ligand
BDBM50256167
Substrate
n/a
Meas. Tech.
ChEMBL_515050 (CHEMBL1034792)
IC50
17000±n/a nM
Citation
 Sparks, SM; Banker, P; Bickett, DM; Carter, HL; Clancy, DC; Dickerson, SH; Dwornik, KA; Garrido, DM; Golden, PL; Nolte, RT; Peat, AJ; Sheckler, LR; Tavares, FX; Thomson, SA; Wang, L; Weiel, JE Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups. Bioorg Med Chem Lett 19:976-80 (2009) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, liver form
Synonyms:
Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:
Homodimer
Mol. Mass.:
97153.98
Organism:
Homo sapiens (Human)
Description:
Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:
847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
  
Inhibitor
Name:
BDBM50256167
Synonyms:
(S)-2-((1s,4R)-4-(hydroxymethyl)cyclohexyl)-2-(3-(3-mesitylureido)-2-naphthamido)acetic acid | CHEMBL475448
Type:
Small organic molecule
Emp. Form.:
C30H35N3O5
Mol. Mass.:
517.616
SMILES:
Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)N[C@@H]([C@@H]2CC[C@H](CO)CC2)C(O)=O)c(C)c1 |r,wU:23.24,24.26,27.29,(7.56,-14.04,;7.55,-12.51,;8.89,-11.72,;8.88,-10.19,;10.21,-9.41,;7.54,-9.43,;7.54,-7.89,;6.2,-7.12,;4.87,-7.9,;6.2,-5.58,;4.86,-4.82,;3.52,-5.59,;2.19,-4.83,;.86,-5.61,;-.48,-4.83,;-.48,-3.29,;.85,-2.52,;2.19,-3.28,;3.51,-2.51,;4.85,-3.27,;6.18,-2.49,;7.52,-3.25,;6.17,-.95,;7.5,-.17,;7.49,1.37,;8.83,2.14,;8.82,3.67,;7.49,4.44,;7.49,5.98,;8.82,6.75,;6.16,3.66,;6.16,2.12,;8.84,-.94,;8.85,-2.47,;10.17,-.16,;6.21,-10.2,;4.88,-9.43,;6.22,-11.74,)|
Structure:
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