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Target
Thromboxane-A synthase
Ligand
BDBM50280264
Substrate
n/a
Meas. Tech.
ChEBML_210288
IC50
15±n/a nM
Citation
 Bhagwat, SS; Roland, DM; Main, AJ; Gude, C; Grim, K; Goldstein, R; Cohen, DS; Dotson, R; Mathis, J; Lee, W Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 7. pyridinylalkyl-substituted arylsulfonylamino arylalkanoic acids. Bioorg Med Chem Lett 2:1623-1626 (1992)    Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50280264
Synonyms:
3-[5-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-2-(2-pyridin-3-yl-ethyl)-phenyl]-propionic acid | CHEMBL297806
Type:
Small organic molecule
Emp. Form.:
C24H25ClN2O4S
Mol. Mass.:
472.984
SMILES:
OC(=O)CCc1cc(CCNS(=O)(=O)c2ccc(Cl)cc2)ccc1CCc1cccnc1
Structure:
Search PDB for entries with ligand similarity: