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Found 182 with Last Name = 'main' and Initial = 'aj'
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036427(CHEMBL350265 | [3,5-Dibromo-4-(4-hydroxy-3-isoprop...)
Affinity DataIC50:  0.100nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036401(CHEMBL163221 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18865(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Affinity DataIC50:  0.110nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036399(Axitirome | CHEMBL159682 | N-(4-{3-[(4-Fluoro-phen...)
Affinity DataIC50:  0.140nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Affinity DataIC50:  0.150nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036402(CHEMBL46882 | N-[3,5-dimethyl-4-(4'-hydroxy-3'-iso...)
Affinity DataIC50:  0.190nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036418(CHEMBL350049 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.230nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036423(CHEMBL164421 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.260nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036411(CHEMBL163324 | N-{3,5-Dichloro-4-[3-(4-chloro-benz...)
Affinity DataIC50:  0.270nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036410(CHEMBL159976 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Affinity DataIC50:  0.310nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036424(CHEMBL159334 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036408(CHEMBL161828 | N-{4-[3-(4-Chloro-benzyl)-4-hydroxy...)
Affinity DataIC50:  0.430nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036417(CHEMBL423977 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Affinity DataIC50:  0.680nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036417(CHEMBL423977 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Affinity DataIC50:  0.680nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036404(CHEMBL159595 | N-(4-{3-[(4-Fluoro-phenyl)-hydroxy-...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036395(CHEMBL350199 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.950nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036420(CHEMBL161535 | N-[4-(3-Isopropyl-4-methoxy-phenoxy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036406(CHEMBL163380 | [3,5-Dichloro-4-(4-hydroxy-3-isopro...)
Affinity DataIC50:  1.10nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036397(CHEMBL348983 | N-[3,5-Dichloro-4-(4-hydroxy-3-isop...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036405(CHEMBL434476 | N-(3,5-Dichloro-4-{3-[(4-chloro-phe...)
Affinity DataIC50:  1.5nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036398(CHEMBL162692 | [3,5-Dibromo-4-(4-hydroxy-3-isoprop...)
Affinity DataIC50:  1.5nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036426(CHEMBL159610 | N-{4-[3-(4-Fluoro-benzoyl)-4-hydrox...)
Affinity DataIC50:  2.5nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036415(CHEMBL163268 | N-[3,5-Dibromo-4-(4-hydroxy-3-isopr...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036414(CHEMBL346112 | N-{4-[3-(4-Chloro-benzoyl)-4-hydrox...)
Affinity DataIC50:  3.30nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036430(CHEMBL347713 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Affinity DataIC50:  3.5nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036422(CHEMBL163020 | N-[3,5-Difluoro-4-(4-hydroxy-3-isop...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003777(8-(4-Chloro-benzenesulfonylamino)-2-(5-pyridin-3-y...)
Affinity DataIC50:  4nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036409((S)-2-Amino-3-[3,5-dibromo-4-(4-hydroxy-3-isopropy...)
Affinity DataIC50:  4.5nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036396(CHEMBL163320 | N-[3,5-Dibromo-4-(4-hydroxy-3-isopr...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280267(CHEMBL295121 | [3-[3-(4-Chloro-benzenesulfonylamin...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzyme from human microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300929((S)-2-amino-3-(4-(4-amino-6-(biphenyl-2-ylmethylam...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant TPH1 by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036432(CHEMBL264041 | N-[4-(3-Isopropyl-phenoxy)-3,5-dime...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280268(3-[3-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-5-(...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzyme from human microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036403(CHEMBL352126 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Affinity DataIC50:  12nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243565((S)-2-amino-3-(4-(5-(naphthalen-2-ylmethylamino)py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300932((S)-2-amino-3-(4-(4-amino-6-((4'-methylbiphenyl-4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant TPH1 by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036412(CHEMBL161245 | N-[4-(3-Isopropyl-4-methoxy-phenoxy...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003779(8-(4-Chloro-benzenesulfonylamino)-6-pyridin-3-ylme...)
Affinity DataIC50:  14nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280264(3-[5-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-2-(...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzyme from human microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291519(3-(3-Biphenyl-4-yl-but-2-enoylamino)-4-methoxy-ben...)
Affinity DataIC50:  16nMAssay Description:In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]-LTB4 from isolated neutrophilsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291521((E)-3-Biphenyl-4-yl-N-[2-methoxy-5-(1H-tetrazol-5-...)
Affinity DataIC50:  17nMAssay Description:In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]-LTB4 from isolated neutrophilsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300935((S)-3-{4-[4-(1-Adamantan-1-yl-ethylamino)-6-amino-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant TPH1 by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003773(8-(4-Chloro-benzenesulfonylamino)-5-(2-pyridin-3-y...)
Affinity DataIC50:  20nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036407(CHEMBL441101 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243613((S)-2-Amino-3-(4-(4-amino-6-((naphthalene-2-ylmeth...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant TPH1 by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243613((S)-2-Amino-3-(4-(4-amino-6-((naphthalene-2-ylmeth...)
Affinity DataIC50:  24nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243618((2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(2...)
Affinity DataIC50:  24nMAssay Description:Inhibition of TPH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 5-hydroxylase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300934((2S)-2-amino-3-(4-(4-amino-6-(1-(biphenyl-4-yl)eth...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant TPH1 by continuous fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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