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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50283732
Substrate
n/a
Meas. Tech.
ChEBML_79815
IC50
0.030000±n/a nM
Citation
 Dorsey, BD; McDaniel, SL; Levin, RB; Vacca, JP; Darke, PL; Zuga, JA; Emini, EA; Schleif, WA; Lin, JH; Chen, IW; Holloway, MK; Anderson, PS; Huff, JR Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitors Bioorg Med Chem Lett 4:2769-2774 (1994)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50283732
Synonyms:
(S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-pyridin-3-yl-pentyl]-4-(quinoline-8-sulfonyl)-piperazine-2-carboxylic acid tert-butylamide | CHEMBL96352
Type:
Small organic molecule
Emp. Form.:
C38H46N6O6S
Mol. Mass.:
714.873
SMILES:
CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@@H](O)C[C@@H](Cc1cccnc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12)S(=O)(=O)c1cccc2cccnc12
Structure:
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