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Target
Isocitrate lyase
Ligand
BDBM50329701
Substrate
n/a
Meas. Tech.
ChEMBL_675509 (CHEMBL1273722)
IC50
28060±n/a nM
Citation
 Oh, KB; Jeon, HB; Han, YR; Lee, YJ; Park, J; Lee, SH; Yang, D; Kwon, M; Shin, J; Lee, HS Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett 20:6644-8 (2010) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_CANAX | ICL1
Type:
PROTEIN
Mol. Mass.:
61398.95
Organism:
Candida albicans
Description:
ChEMBL_972063
Residue:
550
Sequence:
MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA
  
Inhibitor
Name:
BDBM50329701
Synonyms:
CHEMBL491516 | bis(2, 3-dibromo-4,5-dihydroxybenzyl) ether | bis(2,3-dibromo-4,5-dihydroxybenzyl)ether
Type:
Small organic molecule
Emp. Form.:
C14H10Br4O5
Mol. Mass.:
577.842
SMILES:
Oc1cc(COCc2cc(O)c(O)c(Br)c2Br)c(Br)c(Br)c1O
Structure:
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