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Target
Vesicular acetylcholine transporter
Ligand
BDBM50039604
Substrate
n/a
Meas. Tech.
ChEMBL_765941 (CHEMBL1827957)
Ki
0.130000±n/a nM
Citation
 Wang, W; Cui, J; Lu, X; Padakanti, PK; Xu, J; Parsons, SM; Luedtke, RR; Rath, NP; Tu, Z Synthesis and in vitro biological evaluation of carbonyl group-containing analogues fors1 receptors. J Med Chem 54:5362-72 (2011) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50039604
Synonyms:
(+)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidinyl-4''-ol | (-)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidinyl-4''-ol | (3''R,4''R)-1''-(3-Iodo-benzyl)-4-phenyl-[1,3'']bipiperidinyl-4''-ol | CHEMBL1204210 | CHEMBL50880 | trans-1-(3-iodobenzyl)-3-(4-phenylpiperidin-1-yl)piperidin-4-ol
Type:
Small organic molecule
Emp. Form.:
C23H29IN2O
Mol. Mass.:
476.3936
SMILES:
O[C@@H]1CCN(Cc2cccc(I)c2)C[C@H]1N1CCC(CC1)c1ccccc1
Structure:
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