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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50014244
Substrate
n/a
Meas. Tech.
ChEMBL_131453 (CHEMBL740208)
Ki
2.4±n/a nM
Citation
 Maryanoff, BE; Vaught, JL; Shank, RP; McComsey, DF; Costanzo, MJ; Nortey, SO Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem 33:2793-7 (1990) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Dat | Dat1 | Dopamine transporter | SC6A3_MOUSE | Slc6a3 | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68809.06
Organism:
MOUSE
Description:
Dopamine Transporter SLC6A3 MOUSE::Q61327
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQLVDRGEVRQFTLRHWLLV
  
Inhibitor
Name:
BDBM50014244
Synonyms:
10-Methyl-6-(4-methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline; hydrobromide | CHEMBL555462
Type:
Small organic molecule
Emp. Form.:
C20H23NS
Mol. Mass.:
309.468
SMILES:
CSc1ccc(cc1)C1CN2CCCC2c2c(C)cccc12
Structure:
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