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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50160246
Substrate
n/a
Meas. Tech.
ChEMBL_466322 (CHEMBL947039)
Ki
0.76±n/a nM
Citation
 Zeng, F; Jarkas, N; Stehouwer, JS; Voll, RJ; Owens, MJ; Kilts, CD; Nemeroff, CB; Goodman, MM Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorg Med Chem 16:783-93 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50160246
Synonyms:
(2S,3S)-2-[alpha-(2-methoxyphenylthio)phenylmethyl]morpholine | (S)-2-[(R)-(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine | (S)-2-[(S)-(2-Methoxy-phenylsulfanyl)-phenyl-methyl]-morpholine | CHEMBL181188
Type:
Small organic molecule
Emp. Form.:
C18H21NO2S
Mol. Mass.:
315.43
SMILES:
COc1ccccc1S[C@H]([C@@H]1CNCCO1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: