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Target
Synaptic vesicular amine transporter
Ligand
BDBM50442289
Substrate
n/a
Meas. Tech.
ChEMBL_992007 (CHEMBL2447162)
Ki
31±n/a nM
Citation
 Ding, D; Nickell, JR; Deaciuc, AG; Penthala, NR; Dwoskin, LP; Crooks, PA Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorg Med Chem 21:6771-7 (2013) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:
Protein
Mol. Mass.:
55689.58
Organism:
Rattus norvegicus (Rat)
Description:
Q01827
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50442289
Synonyms:
CHEMBL2442143
Type:
Small organic molecule
Emp. Form.:
C21H23NO4
Mol. Mass.:
353.4116
SMILES:
C(Cc1ccc2OCOc2c1)[C@@H]1C[C@@H](CCc2ccc3OCOc3c2)N1 |r|
Structure:
Search PDB for entries with ligand similarity: