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Found 1072 with Last Name = 'crooks' and Initial = 'pa'
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  0.200nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  0.300nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to CB2 receptor (unknown origin)More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50068133((4S,7S,13S)-13-[(S)-2-Amino-3-(4-hydroxy-phenyl)-p...)
Affinity DataKi:  0.300nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  0.400nMAssay Description:Displacement of radiolabeled U69593 from kappa1 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189256(CHEMBL385048 | M3Pr6S)
Affinity DataKi:  0.600nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50381677(CHEMBL1256748 | U-69593)
Affinity DataKi:  0.700nMAssay Description:Displacement of radiolabeled U69593 from kappa1 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189251(CHEMBL213228 | M3P6S)
Affinity DataKi:  0.700nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189252(CHEMBL214040 | M3A6S)
Affinity DataKi:  0.800nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189247(CHEMBL1418 | M6S)
Affinity DataKi:  0.900nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1nMAssay Description:Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranesMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards alpha4-beta2 measured by using the inhibition of [3H]NIC binding to rat striatal membraneMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  1nMAssay Description:Binding affinity to CB2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.10nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50019056((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  1.10nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432198(CHEMBL240913)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]CP 55940 from human CB2 receptor expressed in CHO cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189257(CHEMBL378753 | NalBzOH)
Affinity DataKi:  1.40nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189258(CHEMBL385448 | DM6S)
Affinity DataKi:  1.5nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  2.30nMAssay Description:Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat br...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  2.30nMAssay Description:Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  2.5nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432193(CHEMBL2346979)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]CP 55940 from human CB2 receptor expressed in CHO cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  4nMAssay Description:Inhibition constant against [3H]-nicotine binding to vesicular monoamine transporter-2 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  4.80nMAssay Description:Binding affinity towards alpha-7 neuronal nicotonic acetylcholine receptor (nAChRs) measured by using the inhibition of [3H]-MLA binding to whole bra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189252(CHEMBL214040 | M3A6S)
Affinity DataKi:  5.5nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50121739(Bungarotoxin Neuronal | Bungarotoxin,Alpha | CHEMB...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity towards alpha-7 neuronal nicotonic acetylcholine receptor (nAChRs) measured by using the inhibition of [3H]-MLA binding to whole bra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189247(CHEMBL1418 | M6S)
Affinity DataKi:  6.30nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50019056((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  6.90nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189258(CHEMBL385448 | DM6S)
Affinity DataKi:  7nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432198(CHEMBL240913)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]CP 55940 from CB1 receptor in mouse whole brain membrane homogenates after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50300428(CHEMBL574179 | cis-2,5-Di(2-benzyl)-pyrrolidine)
Affinity DataKi:  9.30nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175681(CHEMBL3809963)
Affinity DataKi:  9.30nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189251(CHEMBL213228 | M3P6S)
Affinity DataKi:  11nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432199(CHEMBL238082)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]CP 55940 from human CB2 receptor expressed in CHO cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50017701(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation countingMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50017701(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175859(CHEMBL3809825)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50175683(CHEMBL3808467)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]DA uptake at VMAT2 in rat striata vesicles homogenate after 8 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50453930(CHEMBL4202598)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat striatal synaptic vesicles by scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50300430(CHEMBL583692 | cis-2,5-Di(3-phenylpropyl)-pyrrolid...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189246(CHEMBL437682 | DM3A6S)
Affinity DataKi:  14nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Cavia porcellus)
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  14nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189251(CHEMBL213228 | M3P6S)
Affinity DataKi:  15nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  16nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189247(CHEMBL1418 | M6S)
Affinity DataKi:  18nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50189258(CHEMBL385448 | DM6S)
Affinity DataKi:  19nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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