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Target
Cannabinoid receptor 2
Ligand
BDBM50042912
Substrate
n/a
Meas. Tech.
ChEMBL_1444655 (CHEMBL3376653)
EC50
10.0±n/a nM
Citation
 Bartolozzi, A; Cirillo, PF; Berry, AK; Hickey, ER; Thomson, DS; Wu, L; Zindell, R; Albrecht, C; Ceci, A; Gemkow, MJ; Nagaraja, NV; Romig, H; Sauer, A; Riether, D Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model. Bioorg Med Chem Lett 25:587-92 (2015) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CNR2_RAT | Cannabinoid CB2 receptor | Cannabinoid receptor | Cnr2 | rCB2
Type:
Enzyme
Mol. Mass.:
39366.68
Organism:
Rattus norvegicus (Rat)
Description:
Q9QZN9
Residue:
360
Sequence:
MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
  
Inhibitor
Name:
BDBM50042912
Synonyms:
CHEMBL3354553
Type:
Small organic molecule
Emp. Form.:
C18H28N4O5S
Mol. Mass.:
412.504
SMILES:
CC(C)(C)c1cc(NC(=O)[C@@H]2CCCCN2C(=O)N2CCS(=O)(=O)CC2)no1 |r|
Structure:
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