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Target
Beta-casein
Ligand
BDBM21447
Substrate
n/a
Meas. Tech.
ChEMBL_1454336 (CHEMBL3364475)
Ki
>1.000000±n/a nM
Citation
 Abet, V; Mariani, A; Truscott, FR; Britton, S; Rodriguez, R Biased and unbiased strategies to identify biologically active small molecules. Bioorg Med Chem 22:4474-89 (2014) [PubMed]  Article 
Target
Name:
Beta-casein
Synonyms:
Antioxidant peptide | Beta-casein | CASB_BOVIN | CK II | CSN2 | Casein Kinase II | Casohypotensin | Casoparan
Type:
Enzyme Mixture
Mol. Mass.:
25102.49
Organism:
Bos taurus (bovine)
Description:
The purified enzyme from bovine brains shows three major bands with apparent molecular masses of 42, 38, and 27 kDa by polyacrylamide gel electrophoresis in sodium dodecyl sulfate.
Residue:
224
Sequence:
MKVLILACLVALALARELEELNVPGEIVESLSSSEESITRINKKIEKFQSEEQQQTEDELQDKIHPFAQTQSLVYPFPGPIPNSLPQNIPPLTQTPVVVPPFLQPEVMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV
  
Inhibitor
Name:
BDBM21447
Synonyms:
4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide | ABT-737 | CHEMBL376408 | N-Benylpiperazine derivative, 2 | US11760752, Compound ABT-737 | US9125913, ABT-737
Type:
Small organic molecule
Emp. Form.:
C42H45ClN6O5S2
Mol. Mass.:
813.427
SMILES:
CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: