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Target
Type-1/Type-2 angiotensin II receptor
Ligand
BDBM50229417
Substrate
n/a
Meas. Tech.
ChEBML_28432
IC50
330±n/a nM
Citation
 Mohan, R; Chou, YL; Bihovsky, R; Lumma, WC; Erhardt, PW; Shaw, KJ Synthesis and biological activity of angiotensin II analogues containing a Val-His replacement, Val psi[CH(CONH2)NH]His. J Med Chem 34:2402-10 (1991) [PubMed]  Article 
Target
Name:
Type-1/Type-2 angiotensin II receptor
Synonyms:
Angiotensin II receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 357784
Components:
This complex has 2 components.
Component 1
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Component 2
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50229417
Synonyms:
CHEMBL2369863
Type:
Small organic molecule
Emp. Form.:
C47H74N14O11
Mol. Mass.:
1011.1777
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)N[C@H](C(N)=O)C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(O)=O |wU:8.7,29.31,45.48,23.25,4.4,15.16,33.35,49.52,2.2,(2.77,5.03,;2.98,3.51,;1.76,2.57,;.33,3.15,;1.97,1.04,;.75,.1,;.95,-1.43,;2.38,-2.01,;-.26,-2.37,;-1.74,-1.94,;-2.61,-3.21,;-1.67,-4.43,;-.22,-3.91,;1.06,-4.78,;2.44,-4.11,;.94,-6.31,;-.17,-7.38,;-1.65,-6.95,;-2.87,-7.89,;-4.14,-7.02,;-3.71,-5.54,;-2.17,-5.5,;2.22,-7.18,;2.1,-8.72,;.71,-9.38,;-.56,-8.52,;.6,-10.92,;3.37,-9.58,;4.76,-8.91,;3.26,-11.12,;4.53,-11.99,;4.42,-13.52,;3.03,-14.19,;5.69,-14.39,;5.58,-15.92,;6.85,-16.79,;8.24,-16.12,;9.51,-16.99,;9.4,-18.52,;10.67,-19.39,;8.01,-19.19,;6.74,-18.33,;7.08,-13.72,;7.19,-12.18,;5.92,-11.32,;8.58,-11.51,;8.69,-9.98,;10.08,-9.31,;11.35,-10.18,;10.2,-7.77,;11.58,-7.11,;11.7,-5.57,;13.08,-4.9,;13.2,-3.36,;14.59,-2.7,;14.7,-1.16,;15.86,-3.56,;8.92,-6.91,;7.54,-7.58,;7.42,-9.11,;6.26,-6.71,;4.88,-7.38,;3.6,-6.51,;9.85,-12.38,;9.74,-13.92,;11.24,-11.71,;1.87,-11.79,;.33,-11.83,;1.76,-13.32,;3.39,.46,;3.6,-1.07,;4.61,1.4,)|
Structure:
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