Reaction Details
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Mitogen-activated protein kinase 1
Ligand
BDBM201717
Substrate
n/a
Meas. Tech.
IMAP-FP Assay
IC50
0.8±n/a nM
Citation
Wilson, KJ; Witter, DJ; Siliphaivanh, P; Lipford, K; Sloman, D; Falcone, D; O'Boyle, B; Mansoor, UF; Lim, J; Methot, JL; Boyce, C; Chen, L; Daniels, MH; Fevrier, S; Huang, X; Kurukulasuriya, R; Tong, L; Zhou, W; Kozlowski, J; Maletic, MM; Shinkre, BA; Thatai, JT; Bakshi, RK; Karunakaran, GB Compounds that are ERK inhibitors US Patent US9233979 Publication Date 1/12/2016 More Info.:
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Inhibitor
Name:
BDBM201717
Synonyms:
US9233979, 148
Type:
Small organic molecule
Emp. Form.:
C20H24N6O2
Mol. Mass.:
380.4436
SMILES:
CCNc1n[nH]c2cc(NC(=O)N[C@H]([C@@H]3CCCO3)c3ccccc3)ncc12 |r|
Structure:
