Reaction Details
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Glutaminyl-peptide cyclotransferase
Ligand
BDBM258436
Substrate
n/a
Meas. Tech.
Inhibitor Assay
pH
8±n/a
Temperature
303.15±n/a K
Ki
31.2±n/a nM
IC50
192±n/a nM
Comments
extracted
Citation
Buchholz, M; Heiser, U; Niestroj, AJ Inhibitors of glutaminyl cyclase US Patent US9512082 Publication Date 12/6/2016 More Info.:
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
Inhibitor
Name:
BDBM258436
Synonyms:
US9512082, 1
Type:
Small organic molecule
Emp. Form.:
C16H22N4O3
Mol. Mass.:
318.3709
SMILES:
COc1ccc(NC(=O)NCCCn2cncc2C)cc1OC
Structure:
