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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497244
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497244
Synonyms:
7-((1R,4S)-4- hydroxycyclohexyl)-5-(1- (methylprolyl)piperidin-4- yl)-2-(((S)-pentan-2- yl)amino)-7H-pyrrolo[2,3- d]pyrimidine | US11001586, Example 16
Type:
Small organic molecule
Emp. Form.:
C28H44N6O2
Mol. Mass.:
496.688
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN1C |r,wU:13.12,wD:3.3,16.16,(-8.33,-2.62,;-7,-1.85,;-5.67,-2.62,;-4.33,-1.85,;-4.33,-.31,;-3,-2.62,;-1.67,-1.85,;-1.67,-.31,;-.33,.46,;1,-.31,;2.47,.16,;3.37,-1.08,;2.47,-2.33,;2.94,-3.79,;4.45,-4.11,;4.92,-5.58,;3.89,-6.72,;4.37,-8.19,;2.39,-6.4,;1.91,-4.94,;1,-1.85,;-.33,-2.62,;2.94,1.63,;4.45,1.95,;4.92,3.41,;3.89,4.56,;2.39,4.24,;1.91,2.77,;4.37,6.02,;3.63,7.38,;5.86,5.62,;6.48,4.22,;8.01,4.38,;8.33,5.88,;7,6.65,;6.84,8.19,)|
Structure:
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