Compile Data Set for Download or QSAR
Report error Found 2979 for UniProtKB: O76074
LigandChemical structure of BindingDB Monomer ID 50316640BDBM50316640(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357238BDBM50357238(CHEMBL1916488)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316638BDBM50316638(1-(2-ethoxyethyl)-3-ethyl-N7-(4-methylpyridin-2-yl...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357243BDBM50357243(CHEMBL1916483)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357241BDBM50357241(CHEMBL1916485)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357240BDBM50357240(CHEMBL1916486)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357234BDBM50357234(CHEMBL1916475)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50556029BDBM50556029(CHEMBL4759667)
Affinity DataIC50: 0.0250nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 150179BDBM150179(US8980904, 4)
Affinity DataIC50: 0.0280nMpH: 7.5 T: 2°CAssay Description:A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50088373BDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50123474BDBM50123474(1-[9-(3-Chloro-4-methoxy-benzylamino)-3-ethyl-3H-2...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357239BDBM50357239(CHEMBL1916487)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50300970BDBM50300970(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357250BDBM50357250(CHEMBL1916476)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316647BDBM50316647(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50241831BDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 0.0440nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50241831BDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 0.0440nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50141580BDBM50141580(4-(3-Chloro-4-methoxy-benzylamino)-8-ethyl-3-hydro...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50300953BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50300964BDBM50300964(rac-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357254BDBM50357254(CHEMBL1916303)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316646BDBM50316646(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027770BDBM50027770(CHEMBL245388)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357263BDBM50357263(CHEMBL1916293)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50300953BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357244BDBM50357244(CHEMBL1916482)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50241831BDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 0.0560nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50241831BDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 0.0560nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50241831BDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 0.0560nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50241831BDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 0.0560nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50241840BDBM50241840(CHEMBL4072903 | US10899756, Compound K)
Affinity DataIC50: 0.0590nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50241840BDBM50241840(CHEMBL4072903 | US10899756, Compound K)
Affinity DataIC50: 0.0590nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50300972BDBM50300972(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50357237BDBM50357237(CHEMBL1916489)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50318137BDBM50318137((R)-3-ethyl-5-(3-methylpiperazin-1-yl)-N-(pyrimidi...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50296256BDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 480487BDBM480487(US10899756, Compound D | US10626113, Compound D)
Affinity DataIC50: 0.0700nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50300983BDBM50300983(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50300976BDBM50300976(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316639BDBM50316639(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316642BDBM50316642((1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 480487BDBM480487(US10899756, Compound D | US10626113, Compound D)
Affinity DataIC50: 0.0700nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50296256BDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316651BDBM50316651(1-(2-ethoxyethyl)-3-ethyl-N-phenyl-5-(piperazin-1-...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 150181BDBM150181(US8980904, 6)
Affinity DataIC50: 0.0750nMpH: 7.5 T: 2°CAssay Description:A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50357264BDBM50357264(CHEMBL1916291)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316644BDBM50316644(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316645BDBM50316645(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50300977BDBM50300977(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(pyrrolidin-1...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316666BDBM50316666(1-(2-ethoxyethyl)-3-ethyl-N5-methyl-N5-(1-methylpi...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
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