Compile Data Set for Download or QSAR
Report error Found 357 of affinity data for UniProtKB/TrEMBL: P04035
LigandPNGBDBM50013216(CHEMBL348798 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50007261(CHEMBL102091 | Sodium; 7-[4-(4-fluoro-phenyl)-2-is...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50013210(CHEMBL162642 | Sodium salt of 7-[4-(4-Fluoro-pheny...)
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50013217(CHEMBL159951 | Sodium salt of7-[1-Cyclohexyl-4-(4-...)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50004774(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50013212(CHEMBL160102 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50013219(CHEMBL2375155 | Sodium salt of7-[1-Cyclohexyl-4-(4...)
Affinity DataIC50: 0.106nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215692(sodium (3R,5R)-7-(5-((4-cyanobenzyl)carbamoyl)-3-(...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50013221(CHEMBL163277 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215688(sodium (3R,5R)-7-(5-((3-(dimethylcarbamoyl)phenyl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215689(sodium (3R,5R)-7-(5-((4-carbamoylphenyl)carbamoyl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215693(sodium (3R,5R)-7-(5-((4-carboxyphenyl)carbamoyl)-3...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215676(sodium (3R,5R)-7-(3-(4-fluorophenyl)-1-isopropyl-8...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215700(sodium (3R,5R)-7-(3-(4-fluorophenyl)-5-((4-hydroxy...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50007272(CHEMBL102168 | Sodium; 6-[4'-fluoro-5-(4-fluoro-ph...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of the incorporation of sodium [14C]acetate into cholesterol in HEP G2 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50013220(CHEMBL161829 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215704(sodium (3R,5R)-7-(5-(((1,5-dimethyl-1H-pyrazol-3-y...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50004774(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

LigandPNGBDBM50215707(sodium (3R,5R)-7-(5-((4-(methoxymethyl)benzyl)carb...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215699(sodium (3R,5R)-7-(3,4-bis(4-fluorophenyl)-5-((3-hy...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215684(sodium (3R,5R)-7-(3-(4-fluorophenyl)-1-isopropyl-4...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215708(sodium (3R,5R)-7-(5-((4-methoxybenzyl)carbamoyl)-3...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215690(sodium (3R,5R)-7-(5-(benzylcarbamoyl)-3-(4-fluorop...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM18372(CHEMBL1496 | Ros | (3R,5S,6E)-7-[4-(4-fluorophenyl...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory constant against HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139181(2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
LigandPNGBDBM155380(US9006282, Example 2, Compound 8 | US9102656, Exam...)
Affinity DataIC50: 1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

LigandPNGBDBM50014820(CHEMBL2368189 | (E)-6-{2-[2-Cyclohexyl-4-(4-fluoro...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholest...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM155374(US9006282, Example 2, Compound 2 | US9102656, Exam...)
Affinity DataIC50: 1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

LigandPNGBDBM155376(US9006282, Example 2, Compound 4 | US9102656, Exam...)
Affinity DataIC50: 1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

LigandPNGBDBM50014828(CHEMBL2368185 | (E)-6-{2-[2,4-Bis-(4-fluoro-phenyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholest...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215698(sodium (3R,5R)-7-(5-((4-(dimethylcarbamoyl)benzyl)...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215694(sodium (3R,5R)-7-(5-((3-carbamoylbenzyl)carbamoyl)...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215683(sodium (3R,5R)-7-(5-((4-(dimethylcarbamoyl)phenyl)...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215691(sodium (3R,5R)-7-(3-(4-fluorophenyl)-1-isopropyl-5...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50007303(CHEMBL318707 | 6-(4'-Fluoro-3,5-diisopropyl-biphen...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of the incorporation of sodium [14C]acetate into cholesterol in HEP G2 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50215666((3R,5R)-7-(3,4-bis(4-fluorophenyl)-1-isopropyl-5-(...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215706(sodium (3R,5R)-7-(5-((3-methoxybenzyl)carbamoyl)-3...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM18374(sodium (3R,5R)-7-[3-(4-fluorophenyl)-4-phenyl-5-(p...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215672(sodium (3R,5R)-7-(5-(3-fluorophenyl)-1-(4-fluoroph...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM155381(US9006282, Example 2, Compound 9 | US9102656, Exam...)
Affinity DataIC50: 2nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

LigandPNGBDBM155382(US9006282, Example 2, Compound 10 | US9102656, Exa...)
Affinity DataIC50: 2nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

LigandPNGBDBM50014826(CHEMBL2368202 | (E)-6-{2-[4,6-Bis-(4-fluoro-phenyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholest...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM155379(US9006282, Example 2, Compound 7 | US9102656, Exam...)
Affinity DataIC50: 2nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

LigandPNGBDBM50004774(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

LigandPNGBDBM50215686(sodium (3R,5R)-7-(5-((4-carboxybenzyl)carbamoyl)-3...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM34168(cid_53232 | SMR000058779 | MLS000069585 | LOVASTAT...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50254788(CHEMBL4088701)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
LigandPNGBDBM50139181(2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory constant against HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215696(sodium (3R,5R)-7-(3-(4-fluorophenyl)-1-isopropyl-5...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50215680(sodium (3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Displayed 1 to 50 (of 357 total ) | Next | Last >>
Jump to: