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Report error Found 3573 for UniProtKB: P08173
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50368152(CHEMBL318812)
Affinity DataKd:  0.00776nMAssay Description:Inhibition of methacholine induced phasic contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataKi:  0.00780nMAssay Description:Displacement of [3H]-NMS from human recombinant M4 receptor expressed in CHO cells after 24 hrs by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50368152(CHEMBL318812)
Affinity DataKd:  0.00800nMAssay Description:Inhibition of methacholine induced phasic contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81768(BENZYLIC ACID | NSC_5311391 | CAS_6581-06-2 | Quin...)
Affinity DataKi:  0.0340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50011851(CHEMBL287868 | 2,2-Diphenyl-propionic acid 6-methy...)
Affinity DataKd:  0.0347nMAssay Description:Inhibition of methacholine induced phasic contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM81768(BENZYLIC ACID | NSC_5311391 | CAS_6581-06-2 | Quin...)
Affinity DataKi:  0.0370nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataIC50: 0.0398nMAssay Description:Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50010096(Hydroxy-diphenyl-acetic acid 1-aza-bicyclo[2.2.2]o...)
Affinity DataKi:  0.0450nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50010096(Hydroxy-diphenyl-acetic acid 1-aza-bicyclo[2.2.2]o...)
Affinity DataKi:  0.0510nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50568740(CHEMBL4860528)
Affinity DataKd:  0.0520nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M4 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50601567(CHEMBL5206565)
Affinity DataKd:  0.0520nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M4 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50601551(CHEMBL5207281)
Affinity DataKd:  0.0520nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M4 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50601574(CHEMBL5201074)
Affinity DataKd:  0.0520nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M4 receptor stably expressed in CHO cells by radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50011851(CHEMBL287868 | 2,2-Diphenyl-propionic acid 6-methy...)
Affinity DataKi:  0.0540nMAssay Description:Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50092313(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfinyl)-p...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451113(CHEMBL2114068)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM86231(CAS_51-55-8 | NSC_3661 | Atropine,(-) | ATROPINE |...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50355622(CHEMBL1910856)
Affinity DataKi:  0.115nMAssay Description:Displacement of [3H]-NMS from human recombinant M4 receptor expressed in CHO cells after 24 hrs by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241132(7-(3-Hydroxy-2-phenyl-propionyloxy)-9,9-dimethyl-3...)
Affinity DataKi:  0.141nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241132(7-(3-Hydroxy-2-phenyl-propionyloxy)-9,9-dimethyl-3...)
Affinity DataKi:  0.141nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50417445(AHR-504 | CUVPOSA | GLYCOPYRROLATE)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50010096(Hydroxy-diphenyl-acetic acid 1-aza-bicyclo[2.2.2]o...)
Affinity DataKi:  0.200nMAssay Description:Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50296331((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phe...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50010096(Hydroxy-diphenyl-acetic acid 1-aza-bicyclo[2.2.2]o...)
Affinity DataKi:  0.240nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50011851(CHEMBL287868 | 2,2-Diphenyl-propionic acid 6-methy...)
Affinity DataKi:  0.270nMAssay Description:Inhibit the binding of [N-mnethyl-3H]-scopolamine [3H]-NMS) to Muscarinic acetylcholine receptor of human IRM-30 neuroblastoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2018
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50471463(CHEMBL331497)
Affinity DataKi:  0.270nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM86231(CAS_51-55-8 | NSC_3661 | Atropine,(-) | ATROPINE |...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM86231(CAS_51-55-8 | NSC_3661 | Atropine,(-) | ATROPINE |...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50368152(CHEMBL318812)
Affinity DataKd:  0.302nMAssay Description:Inhibition of methacholine induced phasic contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50368152(CHEMBL318812)
Affinity DataKd:  0.302nMAssay Description:Inhibition of methacholine induced phasic contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  0.320nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451114(CHEMBL2115128)
Affinity DataKi:  0.320nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50092321(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM86231(CAS_51-55-8 | NSC_3661 | Atropine,(-) | ATROPINE |...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128835(CHEMBL3629360)
Affinity DataKi:  0.350nMAssay Description:Antagonist activity at muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50355610(CHEMBL1237108)
Affinity DataKi:  0.382nMAssay Description:Displacement of [3H]-NMS from human recombinant M4 receptor expressed in CHO cells after 24 hrs by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004656((2-Hydroxyethyl)trimethyl ammonium chloride carbam...)
Affinity DataIC50: 0.400nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50557939(CHEMBL4742721)
Affinity DataKi:  0.417nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M4 expressed in CHO-K9 cell membranes measured after 3 hrs by radioligand competit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50577264(CHEMBL4873386)
Affinity DataIC50: 0.427nMAssay Description:Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50577264(CHEMBL4873386)
Affinity DataIC50: 0.430nMAssay Description:Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50577262(CHEMBL4853244)
Affinity DataIC50: 0.440nMAssay Description:Displacement of [3H]NMS from human muscarinic receptor M4 expressed in CHO cell membranes incubated for 3 hrs by radiometric scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50538317(CHEMBL4636083)
Affinity DataKi:  0.447nMAssay Description:Displacement of [3H]-NMS from human muscarinic M4 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50368152(CHEMBL318812)
Affinity DataKi:  0.449nMAssay Description:Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50265995(CHEMBL4097258)
Affinity DataKi:  0.468nMAssay Description:Displacement of [3H]NMS from human muscarinic acetylcholine receptor M4 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50368152(CHEMBL318812)
Affinity DataKi:  0.475nMAssay Description:Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataIC50: 0.490nMAssay Description:Displacement of [3H]4-DAMP from human recombinant muscarinic M4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataIC50: 0.490nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M4 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176065(CHEMBL76897 | CHEMBL168067 | 4-Diphenylacetoxy-1,1...)
Affinity DataKi:  0.513nMAssay Description:Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic acetylcholine receptor M4 in NG 108-15 CellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50609878(CHEMBL5289601)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in human HEK293T cell membranes by radioligand competition bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 0.575nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced mVen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
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