TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP absent during reaction by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chainMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Inhibition of Clostridium botulinum truncated-BoNT/A light chain 424 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 41nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using N(K)-acetyl)-SNKTRIDEANQRATKML-carboxamide as substrateMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 46nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP absent during reaction by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 77nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 77nMAssay Description:Inhibition of Clostridium botulinum BoNT/A LC assessed as cleavage of SNAP-25 (141 to 206) after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 103nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 157nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP present during reaction by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 162nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP present during reaction by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 171nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of clostridium botulinum Botulinum neurotoxin type A using SNAPide as substrate by FRET analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain (1 to 424 residues) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 285nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum toxin BoNT/A light chainMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chainMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Competitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain using SNAPtide as substrate by FRET based assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Binding affinity to Clostridium botulinum BoNT/A light chain assessed as inhibition constant using SNAPtide as substrate by HPLC assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A using SNAP-25 (141-206) as substrate by HPLC analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 302nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 302nMAssay Description:Competitive inhibition of clostridium botulinum Botulinum neurotoxin type A light chain by RP-HPLC analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 330nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using N(K)-acetyl)-SNKTRIDEANQRATKML-carboxamide as substrateMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 330nMAssay Description:Inhibition of Clostridium botulinum botulinum neurotoxin type A light chainMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal 6XHis-tagged Clostridium botulinum BoNT/A light chain C-terminal truncation mutant (1 to 425 residues) expressed in Escheric...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 341nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 389nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain using SNAPtide as substrate by HPLC assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using SNAP-25 as substrate by FRET analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of Clostridium botulinum BoNT/AMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of Clostridium botulinum toxin BoNT/A light chainMore data for this Ligand-Target Pair
















3D Structure (crystal)








