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TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50512318(CHEMBL4546504)
Affinity DataIC50: 0.0590nMAssay Description:Inhibition of recombinant human full length His-tagged JNK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50032821(CHEMBL3355178)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of JNK2 (unknown origin) by discoverX kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617118(CHEMBL5415466)
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50348537(CHEMBL1801376)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM329334((2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(met...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to JNK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86630(JNK-IN-5)
Affinity DataIC50: 1.93nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50: 1.99nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild-type human full length JNK2 (M1 to Q382 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50215054(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Jnk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50: 2nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50348534(CHEMBL1801373)
Affinity DataIC50: 2nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50: 2nMAssay Description:Inhibition of JNK2 (unknown origin) incubated for 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617112(CHEMBL5432340)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50641322(CHEMBL5564918)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of JNK2 (unknown origin) by HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human JNK2-alpha2 using ATF2 as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JNK2alpha2 by by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617119(CHEMBL5396061)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617120(CHEMBL5436350)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM15908(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-di...)
Affinity DataKi:  4nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM15908(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-di...)
Affinity DataKi:  4nMAssay Description:Inhibition of human JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM15956(N-[4-amino-5-cyano-6-(propan-2-yloxy)pyridin-2-yl]...)
Affinity DataKi:  4nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2-beta-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50578361(CHEMBL4877560)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50352615(CHEMBL1822146)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant JNK2 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50211428(N-ethyl-4-(4-(2-phenyl-1H-indol-3-yl)pyrimidin-2-y...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50578343(CHEMBL4878046)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617110(CHEMBL5397194)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617126(CHEMBL5413843)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617124(CHEMBL5410683)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50578346(CHEMBL4847078)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50641316(CHEMBL5569575)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) by discoverX kinomescan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  5.60nMAssay Description:Average Binding Constant for JNK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50621890(CHEMBL5415503)
Affinity DataKd:  5.80nMAssay Description:Binding affinity to JNK2 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50314147(trans-4-(4-(1-benzyl-5-(dimethylamino)-1H-pyrazol-...)
Affinity DataKi:  6nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Jnk2alpha2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50578347(CHEMBL4853125)
Affinity DataIC50: 6nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 7nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50617121(CHEMBL5436341)
Affinity DataIC50: 7nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  7.30nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
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