BDBM50105742 4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl)-imidazol-1-yl]-cyclohexanol::CHEMBL97162::trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazole

SMILES COc1nccc(n1)-c1c(ncn1[C@H]1CC[C@H](O)CC1)-c1ccc(F)cc1

InChI Key InChIKey=ZQUSFAUAYSEREK-UHFFFAOYSA-N

Data  2 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50105742   

TargetCyclin-dependent kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of cdc2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 14(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of p38delta MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of p38-gamma MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of p38-beta MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 83nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2-beta-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 83nMAssay Description:Inhibition of PKCalpha kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase I isoform delta(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataKi:  25nMAssay Description:Binding affinity to CK1delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCasein kinase I isoform alpha(Human)
Christian-Albrechts University of Kiel

Curated by ChEMBL
LigandPNGBDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataKi:  501nMAssay Description:Binding affinity to CK1a1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed