Compile Data Set for Download or QSAR
Report error Found 67 for UniProtKB: P49662
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50160974BDBM50160974([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against human caspase-4 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50160957BDBM50160957([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against human caspase-4 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200547BDBM50200547(CHEMBL3949842)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50462076BDBM50462076(CHEMBL1091826)
Affinity DataEC50:  16nMAssay Description:Activation of caspase cascade in human T47D cells using N-(Ac-DEVD)-N'-ethoxycarbonyl-R110 fluorogenic substrate incubated for 48 hrs by fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200547BDBM50200547(CHEMBL3949842)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426564BDBM50426564(CHEMBL2323966)
Affinity DataIC50: 90nMAssay Description:Inhibition of caspase-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200544BDBM50200544(CHEMBL3970645)
Affinity DataKi:  119nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200543BDBM50200543(CHEMBL3941088)
Affinity DataKi:  148nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426565BDBM50426565(CHEMBL2324340)
Affinity DataIC50: 180nMAssay Description:Inhibition of caspase-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200550BDBM50200550(CHEMBL3905486)
Affinity DataKi:  207nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200555BDBM50200555(CHEMBL3984293)
Affinity DataKi:  215nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200553BDBM50200553(CHEMBL3898379)
Affinity DataKi:  248nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200556BDBM50200556(CHEMBL3904435)
Affinity DataKi:  267nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200546BDBM50200546(CHEMBL3939229)
Affinity DataKi:  276nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200551BDBM50200551(CHEMBL3978901)
Affinity DataKi:  306nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200544BDBM50200544(CHEMBL3970645)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166683BDBM166683(U74389G (B9))
Affinity DataKi:  337nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426562BDBM50426562(CHEMBL2324339)
Affinity DataIC50: 370nMAssay Description:Inhibition of caspase-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 223313BDBM223313(Tiaprofenic acid)
Affinity DataIC50: 380nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200545BDBM50200545(CHEMBL3965572)
Affinity DataKi:  393nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200543BDBM50200543(CHEMBL3941088)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426566BDBM50426566(CHEMBL2324341)
Affinity DataIC50: 510nMAssay Description:Inhibition of caspase-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200550BDBM50200550(CHEMBL3905486)
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200554BDBM50200554(CHEMBL3968765)
Affinity DataKi:  563nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233673BDBM50233673(cid_3718 | (+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)p...)
Affinity DataIC50: 570nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240374BDBM50240374(4-[1,1'-biphenyl-4-yl]-4-oxobutanoic acid | 3-(4-b...)
Affinity DataIC50: 570nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200555BDBM50200555(CHEMBL3984293)
Affinity DataIC50: 580nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200553BDBM50200553(CHEMBL3898379)
Affinity DataIC50: 670nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200556BDBM50200556(CHEMBL3904435)
Affinity DataIC50: 721nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200546BDBM50200546(CHEMBL3939229)
Affinity DataIC50: 746nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200551BDBM50200551(CHEMBL3978901)
Affinity DataIC50: 826nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 85511BDBM85511(Toradol | KETOROLAC | CAS_74103-07-4 | Ketorolac t...)
Affinity DataIC50: 860nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200548BDBM50200548(CHEMBL3895496)
Affinity DataKi:  870nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 166683BDBM166683(U74389G (B9))
Affinity DataIC50: 909nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200545BDBM50200545(CHEMBL3965572)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200554BDBM50200554(CHEMBL3968765)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 223312BDBM223312(Felbinac)
Affinity DataIC50: 2.00E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200548BDBM50200548(CHEMBL3895496)
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 160786BDBM160786(US9045524, 53 | US10167313, Compound 53)
Affinity DataIC50: 2.80E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
US Patent

TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 160841BDBM160841(US9045524, 111)
Affinity DataIC50: 3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
US Patent

TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 160849BDBM160849(US9045524, 123)
Affinity DataIC50: 3.33E+3nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
US Patent

TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10297BDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  4.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10323BDBM10323(JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-be...)
Affinity DataKi: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50302107BDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of caspase 4 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200549BDBM50200549(CHEMBL3932441)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10298BDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  5.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50200552BDBM50200552(CHEMBL3898411)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DTT-activated caspase-4 expressed in Escherichia coli using Ac-LEVD-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426563BDBM50426563(CHEMBL2323967)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of caspase-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303417BDBM50303417(4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1...)
Affinity DataIC50: 8.13E+3nMAssay Description:Inhibition of human Caspase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCaspase-4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50009859BDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 8.80E+3nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2017
Entry Details Article
PubMed
Displayed 1 to 50 (of 67 total ) | Next | Last >>
Jump to: