Compile Data Set for Download or QSAR
Report error Found 3056 for UniProtKB: P49768
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477148BDBM50477148(CHEMBL235870)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of human gamma secretase in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477143BDBM50477143(CHEMBL392113)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of human gamma secretase assessed as amyloid-beta40 peptide production in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477136BDBM50477136(CHEMBL235659)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human gamma secretase assessed as amyloid-beta40 peptide production in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477131BDBM50477131(CHEMBL235869)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of human gamma secretase in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480056BDBM50480056(CHEMBL468083)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477131BDBM50477131(CHEMBL235869)
Affinity DataIC50: 0.0370nMAssay Description:Inhibition of human gamma secretase assessed as amyloid-beta40 peptide production in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50185404BDBM50185404((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-1-...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477136BDBM50477136(CHEMBL235659)
Affinity DataIC50: 0.0420nMAssay Description:Inhibition of human gamma secretase in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477060BDBM50477060(CHEMBL393761)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480051BDBM50480051(CHEMBL512282)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480052BDBM50480052(CHEMBL467457)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480057BDBM50480057(CHEMBL523832)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480058BDBM50480058(CHEMBL495009)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50185410BDBM50185410((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480062BDBM50480062(CHEMBL511572)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477143BDBM50477143(CHEMBL392113)
Affinity DataIC50: 0.0750nMAssay Description:Inhibition of human gamma secretase in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480065BDBM50480065(CHEMBL495185)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477067BDBM50477067(CHEMBL237875)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50185411BDBM50185411((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241259BDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP 695 assessed as reduction in amyloid beta levels after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241259BDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataIC50: 0.0820nMAssay Description:Inhibition of gamma secretase in HEK293 cells assessed as reduction in amyloid beta40 level incubated for 4 hrs by electrochemiluminescence detection...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477134BDBM50477134(CHEMBL393542)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human gamma secretase assessed as amyloid-beta40 peptide production in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477038BDBM50477038(CHEMBL237850)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477048BDBM50477048(CHEMBL236597)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241259BDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataEC50:  0.114nMAssay Description:Reduction of human wild type PS1-induced amyloid beta-40 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480059BDBM50480059(CHEMBL523883)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458169BDBM50458169(Avagacestat | BMS 708163 | BMS-708163 | BMS-708163...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241259BDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataEC50:  0.135nMAssay Description:Reduction of human wild type PS1-induced amyloid beta-42 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50410179BDBM50410179(CHEMBL2096800)
Affinity DataIC50: 0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477051BDBM50477051(CHEMBL237666)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480063BDBM50480063(CHEMBL511928)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480066BDBM50480066(CHEMBL494588)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50481062BDBM50481062(CHEMBL583904)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50481056BDBM50481056(CHEMBL572032)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593499BDBM50593499(CHEMBL5202466)
Affinity DataIC50: 0.178nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485444BDBM50485444(CHEMBL2059813)
Affinity DataIC50: 0.178nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485806BDBM50485806(CHEMBL2164125)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human gamma-secretase expressed in IMR32 cell membranes using MBPC-125 Swedish as substrate assessed as inhibition of amyloid beta40 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50185407BDBM50185407((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50135575BDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50481086BDBM50481086(CHEMBL571602)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477513BDBM50477513(CHEMBL392246)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50480050BDBM50480050(CHEMBL511375)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50481087BDBM50481087(CHEMBL571145)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477134BDBM50477134(CHEMBL393542)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human gamma secretase in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477065BDBM50477065(CHEMBL236592)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50492082BDBM50492082(CHEMBL2396959)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477046BDBM50477046(CHEMBL236595)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593498BDBM50593498(CHEMBL5198066)
Affinity DataIC50: 0.225nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458169BDBM50458169(Avagacestat | BMS 708163 | BMS-708163 | BMS-708163...)
Affinity DataIC50: 0.225nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50477923BDBM50477923(CHEMBL437977)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
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