Compile Data Set for Download or QSAR
Report error Found 706 of affinity data for UniProtKB/TrEMBL: P53985
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21995BDBM21995(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  0.0900nM ΔG°:  -56.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22000BDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.0955nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22000BDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.100nM ΔG°:  -56.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50180647BDBM50180647(CHEMBL3818777)
Affinity DataEC50:  0.160nMAssay Description:Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22001BDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.275nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22001BDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.280nM ΔG°:  -54.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22009BDBM22009(5-{[(1R,3R)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  0.290nM ΔG°:  -53.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22001BDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.302nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21992BDBM21992(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  0.310nM ΔG°:  -53.7kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21986BDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50637416BDBM50637416(CHEMBL5559179)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22001BDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21986BDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21986BDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nM ΔG°:  -53.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21986BDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.331nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22002BDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22002BDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.355nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22002BDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.355nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22010BDBM22010(5-{[(1R,3S)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21996BDBM21996(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  0.430nM ΔG°:  -52.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21994BDBM21994(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  0.520nM ΔG°:  -52.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22011BDBM22011(5-{[(1S,3R,4S)-3,4-dihydroxycyclopentyl]sulfanyl}-...)
Affinity DataKi:  0.680nM ΔG°:  -51.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22000BDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.708nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22025BDBM22025(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50180643BDBM50180643(CHEMBL3818311)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50180645BDBM50180645(CHEMBL3817951)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50180648BDBM50180648(CHEMBL3818150)
Affinity DataEC50:  0.800nMAssay Description:Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21987BDBM21987(6-[(6-fluoroquinolin-4-yl)methyl]-5-{[(3R)-3-hydro...)
Affinity DataKi:  0.810nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22014BDBM22014(5-{[(3R)-3-hydroxypyrrolidine-1-]sulfonyl}-3-methy...)
Affinity DataKi:  1.10nM ΔG°:  -50.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21986BDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  1.17nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21998BDBM21998(6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{[(4S)-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human MCT1 assessed as inhibition constant preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21998BDBM21998(6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{[(4S)-...)
Affinity DataKi:  1.20nM ΔG°:  -50.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50103571BDBM50103571(CHEMBL3335793)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to MCT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21997BDBM21997(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50103571BDBM50103571(CHEMBL3335793)
Affinity DataKi:  2nMAssay Description:Binding affinity to MCT1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22004BDBM22004(3-methyl-1-(2-methylpropyl)-5-(propan-2-ylsulfanyl...)
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22008BDBM22008(5-{[(1R,2R)-2-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  2.70nM ΔG°:  -48.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22006BDBM22006(5-(cyclopentylsulfanyl)-3-methyl-1-(2-methylpropyl...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22025BDBM22025(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21993BDBM21993(6-[(4,5-dichloro-2-methyl-1H-imidazol-1-yl)methyl]...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50416571BDBM50416571(CHEMBL1221551)
Affinity DataKi:  3.39nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50416571BDBM50416571(CHEMBL1221551)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22020BDBM22020(5-[(3-hydroxy-3-methylazetidin-1-yl)carbonyl]-3-me...)
Affinity DataKi:  3.5nM ΔG°:  -47.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22024BDBM22024(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(iso...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 50180649BDBM50180649(CHEMBL3818851)
Affinity DataEC50:  4nMAssay Description:Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22026BDBM22026(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.70nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21985BDBM21985(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 21985BDBM21985(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22015BDBM22015(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  4.90nM ΔG°:  -47.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2008
Entry Details Article
PubMed
TargetMonocarboxylate transporter 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 22000BDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataEC50:  5nMAssay Description:Inhibition of MCT1 in human Raji cells assessed as inhibition of cell proliferation after 96 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
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