Compile Data Set for Download or QSAR
Report error Found 206 for UniProtKB: P70604
LigandChemical structure of BindingDB Monomer ID 50260153BDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataKi:  0.00400nMAssay Description:Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 392076BDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.0120nMAssay Description:Displacement of [125I]apamin from rat brain SkCa channel after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50155248BDBM50155248(CHEMBL3774478)
Affinity DataIC50: 0.0160nMAssay Description:Displacement of [125I]apamin from rat cerebral cortex small conductance calcium-activated potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50561183BDBM50561183(CHEMBL4787693)
Affinity DataEC50:  0.0240nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50561185BDBM50561185(CHEMBL4749661)
Affinity DataEC50:  0.0270nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50561184BDBM50561184(CHEMBL4762592)
Affinity DataEC50:  0.290nMAssay Description:Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50092131BDBM50092131(CHEMBL612120 | UCL-1848 | CHEMBL420873 | 1,7-diazo...)
Affinity DataIC50: 2nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50061977BDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50061977BDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474856BDBM50474856(CHEMBL184300)
Affinity DataIC50: 9nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474870BDBM50474870(CHEMBL185146)
Affinity DataIC50: 10nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474869BDBM50474869(CHEMBL181911)
Affinity DataIC50: 12nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474865BDBM50474865(CHEMBL183644)
Affinity DataIC50: 15nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474867BDBM50474867(CHEMBL184858)
Affinity DataIC50: 16nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476799BDBM50476799(CHEMBL397282)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474866BDBM50474866(CHEMBL181912)
Affinity DataIC50: 25nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473100BDBM50473100(CHEMBL344807)
Affinity DataIC50: 25nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473103BDBM50473103(CHEMBL430146)
Affinity DataIC50: 28nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473103BDBM50473103(CHEMBL430146)
Affinity DataIC50: 28nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474868BDBM50474868(CHEMBL184891)
Affinity DataIC50: 30nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474871BDBM50474871(CHEMBL182716)
Affinity DataIC50: 31nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476809BDBM50476809(CHEMBL394773)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476802BDBM50476802(CHEMBL395568)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474863BDBM50474863(CHEMBL360624)
Affinity DataIC50: 35nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474872BDBM50474872(CHEMBL1180184)
Affinity DataIC50: 40nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476800BDBM50476800(CHEMBL242790)
Affinity DataKi:  42nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473097BDBM50473097(CHEMBL136488)
Affinity DataIC50: 60nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474858BDBM50474858(CHEMBL186139)
Affinity DataIC50: 60nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50150389BDBM50150389(17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474859BDBM50474859(CHEMBL185258)
Affinity DataIC50: 65nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473106BDBM50473106(CHEMBL137175)
Affinity DataIC50: 70nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473106BDBM50473106(CHEMBL137175)
Affinity DataIC50: 70nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50084848BDBM50084848(BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...)
Affinity DataIC50: 80nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084848BDBM50084848(BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...)
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandChemical structure of BindingDB Monomer ID 50473094BDBM50473094(CHEMBL137155)
Affinity DataIC50: 90nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50289333BDBM50289333(21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.1...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandChemical structure of BindingDB Monomer ID 50476798BDBM50476798(CHEMBL242789)
Affinity DataKi:  90nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583213BDBM50583213(CHEMBL5086997)
Affinity DataEC50:  91nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473098BDBM50473098(CHEMBL342213)
Affinity DataIC50: 100nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476801BDBM50476801(CHEMBL241952)
Affinity DataKi:  106nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084852BDBM50084852(4N-[10-(1-methyl-4-quinoliniumylamino)decyl]-1-[3-...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50583211BDBM50583211(CHEMBL5078247)
Affinity DataEC50:  110nMAssay Description:Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50084852BDBM50084852(4N-[10-(1-methyl-4-quinoliniumylamino)decyl]-1-[3-...)
Affinity DataIC50: 110nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473099BDBM50473099(CHEMBL140380)
Affinity DataIC50: 120nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50474857BDBM50474857(CHEMBL185106)
Affinity DataIC50: 130nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473107BDBM50473107(CHEMBL341700)
Affinity DataIC50: 130nMAssay Description:Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50473107BDBM50473107(CHEMBL341700)
Affinity DataIC50: 130nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476807BDBM50476807(CHEMBL242791)
Affinity DataKi:  132nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50084849BDBM50084849(Bis-quinolinium cyclophane analogue | Cyclo(N-deca...)
Affinity DataIC50: 150nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Rat)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084849BDBM50084849(Bis-quinolinium cyclophane analogue | Cyclo(N-deca...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

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