Compile Data Set for Download or QSAR
Report error Found 52 of affinity data for UniProtKB/TrEMBL: Q5S006
LigandChemical structure of BindingDB Monomer ID 50582730BDBM50582730(CHEMBL5087055)
Affinity DataIC50: 11nMAssay Description:Inhibition of LRRK2-WT in C57BL/6 mouse brain at 10 to 150 mg/kg and measured after 1 hrs by western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50629808BDBM50629808(CHEMBL5438272)
Affinity DataIC50: 15nMAssay Description:PROTAC activity at CRBN/LRRK2 in mouse RAW264.7 cells assessed as reduction of protein degradation measured after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50582730BDBM50582730(CHEMBL5087055)
Affinity DataIC50: 16nMAssay Description:Inhibition of LRRK2-WT-pSER935 in C57BL/6 mouse brain at 10 to 150 mg/kg and measured after 1 hrs by western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50582731BDBM50582731(CHEMBL5092087)
Affinity DataIC50: 22nMAssay Description:Inhibition of LRRK2-WT in C57BL/6 mouse brain at 10 to 150 mg/kg and measured after 1 hrs by western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50582731BDBM50582731(CHEMBL5092087)
Affinity DataIC50: 23nMAssay Description:Inhibition of LRRK2-WT-pSER935 in C57BL/6 mouse brain at 10 to 150 mg/kg and measured after 1 hrs by western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 257207BDBM257207(US9493440, 51)
Affinity DataEC50:  30nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50629804BDBM50629804(CHEMBL5437266)
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597171BDBM50597171(CHEMBL5170238)
Affinity DataEC50:  260nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597182BDBM50597182(CHEMBL5181966)
Affinity DataEC50:  280nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597160BDBM50597160(CHEMBL5177578)
Affinity DataEC50:  290nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597161BDBM50597161(CHEMBL5173029)
Affinity DataEC50:  340nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597178BDBM50597178(CHEMBL5174380)
Affinity DataEC50:  390nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597177BDBM50597177(CHEMBL5172291)
Affinity DataEC50:  390nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597172BDBM50597172(CHEMBL5187306)
Affinity DataEC50:  600nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597166BDBM50597166(CHEMBL5198878)
Affinity DataEC50:  600nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597176BDBM50597176(CHEMBL5170225)
Affinity DataEC50:  690nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597162BDBM50597162(CHEMBL5200500)
Affinity DataEC50:  750nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597164BDBM50597164(CHEMBL5179102)
Affinity DataEC50:  760nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597153BDBM50597153(CHEMBL5197009)
Affinity DataEC50:  800nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597165BDBM50597165(CHEMBL5190962)
Affinity DataEC50:  920nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597157BDBM50597157(CHEMBL5204372)
Affinity DataEC50:  1.08E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597175BDBM50597175(CHEMBL5199239)
Affinity DataEC50:  1.28E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597158BDBM50597158(CHEMBL5185437)
Affinity DataEC50:  1.38E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597180BDBM50597180(CHEMBL5194234)
Affinity DataEC50:  1.44E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597154BDBM50597154(CHEMBL5202841)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597179BDBM50597179(CHEMBL5198203)
Affinity DataEC50:  1.71E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597148BDBM50597148(CHEMBL5196289)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597163BDBM50597163(CHEMBL5190480)
Affinity DataEC50:  2.31E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597181BDBM50597181(CHEMBL5207639)
Affinity DataEC50:  3.12E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597149BDBM50597149(CHEMBL5185136)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597173BDBM50597173(CHEMBL5202898)
Affinity DataEC50:  4.78E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597169BDBM50597169(CHEMBL5198788)
Affinity DataEC50:  4.90E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597144BDBM50597144(CHEMBL5205363)
Affinity DataEC50:  5.10E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597182BDBM50597182(CHEMBL5181966)
Affinity DataEC50:  5.40E+3nMAssay Description:Inhibition of mouse full-length wild type LRRK2 transfected in HEK293 cells using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597155BDBM50597155(CHEMBL5199105)
Affinity DataEC50:  6.40E+3nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597146BDBM50597146(CHEMBL5188336)
Affinity DataEC50:  1.22E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597147BDBM50597147(CHEMBL5183984)
Affinity DataEC50:  1.22E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597167BDBM50597167(CHEMBL5207466)
Affinity DataEC50:  1.34E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597170BDBM50597170(CHEMBL5195211)
Affinity DataEC50:  1.43E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597152BDBM50597152(CHEMBL5191932)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597159BDBM50597159(CHEMBL5208171)
Affinity DataEC50:  1.67E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597174BDBM50597174(CHEMBL5170423)
Affinity DataEC50:  1.96E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597168BDBM50597168(CHEMBL5185379)
Affinity DataEC50:  2.17E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597151BDBM50597151(CHEMBL5207757)
Affinity DataEC50:  5.70E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597154BDBM50597154(CHEMBL5202841)
Affinity DataEC50:  7.60E+4nMAssay Description:Inhibition of mouse full-length wild type LRRK2 transfected in HEK293 cells using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597145BDBM50597145(CHEMBL5198175)
Affinity DataEC50:  8.00E+4nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597156BDBM50597156(CHEMBL5173076)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597178BDBM50597178(CHEMBL5174380)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of mouse full-length wild type LRRK2 transfected in HEK293 cells using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597150BDBM50597150(CHEMBL5184765)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50597148BDBM50597148(CHEMBL5196289)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of mouse full-length wild type LRRK2 transfected in HEK293 cells using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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