Compile Data Set for Download or QSAR
Report error Found 384 of affinity data for UniProtKB/TrEMBL: Q63380
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50308250((1R,5R,6R)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)...)
Affinity DataKi:  0.135nMAssay Description:Displacement of [N-methyl-3H]nisoxetine from rat hippocampus NET by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124566(2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine | ...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]nisoxetine from rat NET in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50198230((S)-2-((S)-(2-iodophenoxy)(phenyl)methyl)morpholin...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322698(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]nisoxetine from NET in rat hippocampus after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]nisoxetine from rat NET in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to rat NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  4nMAssay Description:Inhibition of NET in rat synaptosomal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50366567(ATOMOXETINE)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50444862(CHEMBL3099493)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330790(N-Methyl-3-phenyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]nisoxetine from rat NET in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50275774(N,N-Diallyl (1R,2R)-2-(Aminomethyl)-1-(2-thienyl)c...)
Affinity DataIC50: 4.60nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM22417(LY 94939 | Nisoxetine Inhibitor | Nisoxetine | LY1...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50444861(CHEMBL3099494)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401730(CHEMBL2206509)
Affinity DataKi:  6.30nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50: 6.40nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254049((S)-N-methyl-4-(naphthalen-1-yl)-4-(thiophen-2-yl)...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50444860(CHEMBL3099495)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50301211((2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine ...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]nisoxetine from NAT in Sprague-Dawley rat brain after 4 hrs by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254073((S)-4-(1H-indol-4-yl)-N-methyl-4-(thiophen-2-yl)bu...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50009717(CHEMBL436281)
Affinity DataIC50: 10nMAssay Description:Inhibition of NET-mediated norepinephrine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50190608(cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-(4...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254071((S)-3-(1H-indol-4-yl)-N-methyl-3-(thiophen-2-yl)pr...)
Affinity DataKi:  13.8nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330791(N-Methyl-4-phenyl-4-(4-(2-(pyrrolidin-1-yl)ethoxy)...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]nisoxetine from rat NET in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330787(4-(3-(Methylamino)-1-phenylpropyl)-6-(2-(pyrrolidi...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]nisoxetine from rat NET in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 15nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50275771(1S,2R-milnacipran | CHEMBL471001)
Affinity DataIC50: 16nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataKi:  20nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50303309(3-(3,4-dichlorophenyl)-2-nortropene | CHEMBL578130)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]nisoxetine from NET in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50275773(N-Ethyl-N-(2-fluoroallyl) (1R,2R)-2-(Aminomethyl)-...)
Affinity DataIC50: 21nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM82217([4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphth...)
Affinity DataIC50: 22nMAssay Description:Inhibition of [3H]norepinephrine reuptake at NET in rat brain synaptosome by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50190601((2S,4R,5R)-2-benzhydryl-5-[(1H-indol-5-ylmethyl)-a...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243939((cis)-1-(3,4-dichlorophenyl)-6-methyl-3-aza-bicycl...)
Affinity DataIC50: 29nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 30nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50190603(cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-(4...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM138157(US8877798, Table 3, Structure 3)
Affinity DataKi:  32nMAssay Description:Binding assay using NET, DAT and SERT enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
US Patent

TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243940((cis)-1-(3,4-dichlorophenyl)-6-phenyl-3-aza-bicycl...)
Affinity DataIC50: 34nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254111((S)-3-(3,4-dichlorophenyl)-3-(1H-indol-4-yl)-N-met...)
Affinity DataKi:  35.4nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243942(1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 36nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50444871(CHEMBL3099502)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  48nMAssay Description:Binding affinity to rat NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243986(1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 48nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 51nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254047((S)-N-methyl-3-(naphthalen-1-yl)-3-(thiophen-2-yl)...)
Affinity DataKi:  52.1nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243987(1-(benzo[b]thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 53nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
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