BDBM50239791 (1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophen-3-yl)cyclopropanecarboxamide::CHEMBL257602

SMILES CCN(CC=C)C(=O)[C@]1(C[C@H]1CN)c1ccsc1

InChI Key InChIKey=NYOJDMQJBPXCHG-GXTWGEPZSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50239791   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50:  6.40nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50:  27nMAssay Description:Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from rat synaptosomal SERT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from rat synaptosomal DAT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50:  140nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed