Compile Data Set for Download or QSAR
Report error Found 85 of affinity data for UniProtKB/TrEMBL: Q91ZY1
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509072(CHEMBL4454158)
Affinity DataEC50:  0.0501nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509078(CHEMBL4443126)
Affinity DataEC50:  0.617nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509065(CHEMBL4439142)
Affinity DataEC50:  0.646nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509074(CHEMBL4543119)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509064(CHEMBL4445423)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26399(14-fluoro-6-(piperazin-1-yl)-3,5-diazatricyclo[9.4...)
Affinity DataKi:  1.45nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50415770(CHEMBL1079516)
Affinity DataKi:  1.45nMAssay Description:Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50361015(CHEMBL592379)
Affinity DataKi:  1.55nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509071(CHEMBL4455324)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity of compound towards rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  2.60nM ΔG°:  -49.0kJ/molepH: 7.5 T: 2°CAssay Description:The Ki values were calculated based on an experimentally determined appropriate Kd value according to Cheng and Prusoff.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2008
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50415769(CHEMBL1089390)
Affinity DataKi:  2.63nMAssay Description:Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50415767(CHEMBL1077276)
Affinity DataKi:  2.69nMAssay Description:Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50415768(CHEMBL1089040)
Affinity DataKi:  3.24nMAssay Description:Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50133004((7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity of compound towards rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26226((12S,17S)-6-(piperazin-1-yl)-11-oxa-3,5-diazatetra...)
Affinity DataKi:  3.40nM ΔG°:  -48.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26398(6-[3-(methylamino)azetidin-1-yl]-3,5-diazatricyclo...)
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26396(A-943931 | 6-[(3R)-3-aminopyrrolidin-1-yl]-3,5-dia...)
Affinity DataKi:  3.80nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26391(5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole | JN...)
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  4.27nMAssay Description:Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26400(9-phenyl-4-(piperazin-1-yl)-5H,6H,7H,8H,9H-cyclohe...)
Affinity DataKi:  4.47nMAssay Description:Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26400(9-phenyl-4-(piperazin-1-yl)-5H,6H,7H,8H,9H-cyclohe...)
Affinity DataKi:  4.5nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  4.70nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26394(4-(piperazin-1-yl)-5H-indeno[1,2-d]pyrimidin-2-ami...)
Affinity DataKi:  4.80nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26397(6-[(3R)-3-(methylamino)pyrrolidin-1-yl]-3,5-diazat...)
Affinity DataKi:  5.10nM ΔG°:  -47.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26392(6-(4-methylpiperazin-1-yl)-3,5-diazatricyclo[8.4.0...)
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  6nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26395(6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}...)
Affinity DataKi:  7.60nM ΔG°:  -46.3kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26393(6-(piperazin-1-yl)-3,5-diazatricyclo[8.4.0.0^{2,7}...)
Affinity DataKi:  9.20nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50483137(CHEMBL1632413)
Affinity DataEC50:  10nMAssay Description:Agonist activity at rat histamine H4 receptor by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50356884(CHEMBL1915540)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50356884(CHEMBL1915540)
Affinity DataKi:  12.3nMAssay Description:Displacement of [3H]-histamine from rat H4R expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50412494(VUF-10497 | CHEMBL452847)
Affinity DataKi:  15.8nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50483138(CHEMBL1632414)
Affinity DataKi:  16nMAssay Description:Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509072(CHEMBL4454158)
Affinity DataEC50:  17nMAssay Description:Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50483137(CHEMBL1632413)
Affinity DataKi:  20nMAssay Description:Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  22nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  22nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509075(CHEMBL4437371)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50397292(VUF-10499 | CHEMBL454890)
Affinity DataKi:  24.6nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509065(CHEMBL4439142)
Affinity DataEC50:  26nMAssay Description:Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50433358(CHEMBL2376803)
Affinity DataKi:  28nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509078(CHEMBL4443126)
Affinity DataEC50:  30nMAssay Description:Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50433359(CHEMBL2376804)
Affinity DataKi:  30nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509071(CHEMBL4455324)
Affinity DataEC50:  34nMAssay Description:Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  34nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  34nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
Displayed 1 to 50 (of 85 total ) | Next | Last >>
Jump to: