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Found 4 Enz. Inhib. hit(s) with Target = 'Histamine H4 receptor' and Ligand = 'BDBM26392'
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  15.5nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataEC50:  295nMAssay Description:Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed