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TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366693(CHEMBL1793812)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218940(CHEMBL1793991)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50101331(CHEMBL3329621)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366696(CHEMBL1793811)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366738(CHEMBL1793985)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366712(CHEMBL1793822)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50588302(CHEMBL5199116)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50588303(CHEMBL5170036)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366713(CHEMBL1793816)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC10 (1 to 481 residues) expressed in baculovirus infected Sf9 insect cells using B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50101330(CHEMBL3329622)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50530002(CHEMBL4532398)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of recombinant full length N-terminal FLAG-tagged human HDAC10 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50530002(CHEMBL4532398)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of recombinant full length N-terminal FLAG-tagged human HDAC10 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50188899(CHEMBL3827517)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of human recombinant HDAC10 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50649001(CHEMBL5618885)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 1nMAssay Description:Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50027494(CHEMBL3356916)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC10 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366706(CHEMBL1793810)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full-length human HDAC10 using FITC-H3K27(Ac)-NH2 as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50531374(CHEMBL4467135)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218879(CHEMBL1793947)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218877(CHEMBL1793823)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141381(CHEMBL3758184)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract using Fluor de lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50463739(CHEMBL4237803)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218931(CHEMBL1793992)
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50530003(CHEMBL4552057)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant full length N-terminal FLAG-tagged human HDAC10 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50530003(CHEMBL4552057)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant full length N-terminal FLAG-tagged human HDAC10 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079798(CHEMBL99661)
Affinity DataIC50: 1.40nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  1.5nMAssay Description:Inhibition of purified recombinant human HDAC10 assessed as inhibition constant using residues 379-382 (RHKK(Ac)AMC) fluorogenic substrate p53 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50555460(CHEMBL4785064)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478829(6-(6-Methoxynaphthalyl)Triazolylhexahydroxamic Aci...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478811(6-(3-Biphenyl)Triazolylhexahydroxamic Acid | CHEMB...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50460430(CHEMBL4228304)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50512068(CHEMBL4526274)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082325(CHEMBL99392)
Affinity DataIC50: 2nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50514463(CHEMBL4460552)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human His6/GST-tagged HDAC10 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
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