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Report error Found 19 of affinity data for UniProtKB/TrEMBL: Q9NQV7
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PRDM9 using Histone H3 and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PRDM9 using Histone H3 and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50652788(CHEMBL4791017)
Affinity DataKi:  65nMAssay Description:Competitive inhibition of PRDM9 (unknown origin) assessed as inhibition constant in presence of varying concentration of SAM and peptide substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50652788(CHEMBL4791017)
Affinity DataIC50: 80nMAssay Description:Inhibition of PRDM9 (unknown origin) (195 to 415 residues) using biotin-tagged Histone H3 (1 to 25) and 3H-SAM as substrate incubated for 30 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50652788(CHEMBL4791017)
Affinity DataKd:  87nMAssay Description:Binding affinity to PRDM9 (unknown origin) (195 to 415 residues) assessed as dissociation constant measured at 60 to 120 secs in presence of SAM by b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50652788(CHEMBL4791017)
Affinity DataIC50: 800nMAssay Description:Inhibition of FLAG tagged PRDM9 transfected in HEK293T cells assessed as reduction in trimethylation of ectopic H3K4 measured after 20 hrs by Western...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228646(MARTKQTARKSTGGKAPRKQLATKA | H3 (1-25) K4me0)
Affinity DataKd:  3.60E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228651(LATKAARKSAPSTGGVKKPHRYRP | H3 (21-44) K36me1)
Affinity DataKd:  4.10E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228652(LATKAARKSAPSTGGVKKPHRYRP | H3 (21-44) K36me2)
Affinity DataKd:  4.20E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228650(LATKAARKSAPSTGGVKKPHRYRP | H3 (21-44) K36me0)
Affinity DataKd:  4.60E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228647(MARTKQTARKSTGGKAPRKQLATKA | H3 (1-25) K4me1)
Affinity DataKd:  4.70E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae GST-tagged Fab1 incubated for 15 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228648(MARTKQTARKSTGGKAPRKQLATKA | H3 (1-25) K4me2)
Affinity DataKd:  5.80E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228653(LATKAARKSAPSTGGVKKPHRYRP | H3 (21-44) K36me3)
Affinity DataKd:  9.60E+3nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM31767(3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae GST-tagged Fab1 incubated for 15 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9 [195-385](Human)
University of Toronto

LigandPNGBDBM228649(MARTKQTARKSTGGKAPRKQLATKA | H3 (1-25) K4me3)
Affinity DataKd:  1.20E+4nMpH: 8.5 T: 2°CAssay Description:In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details Article
PubMed